Covington Brodersen

Consistently, the staining pattern of γH2AX-foci is significantly reduced in the cells exposed simultaneously to cisplatin and FH535; and (5) inhibition of Wnt/β-catenin signalling impedes cisplatin-induced phosphorylation of Chk1, abrogates the G2/M phase arrest and impairs recombination-based DNA repair. Our data further show that Wnt s…[Read more]

Consistently, the staining pattern of γH2AX-foci is significantly reduced in the cells exposed simultaneously to cisplatin and FH535; and (5) inhibition of Wnt/β-catenin signalling impedes cisplatin-induced phosphorylation of Chk1, abrogates the G2/M phase arrest and impairs recombination-based DNA repair. Our data further show that Wnt s…[Read more]

en by natural selection appeared to occur rapidly during evolutionary history. Notably, the utility of commercial N. atra and B. multicinctus antivenoms against H. curtus toxins was not comprehensive; thus, the development of species-specific antivenom is urgently needed.

Our study clarified the venom-gland transcriptomic and venomic profiles…[Read more]

Background Cancer is one of the deadliest diseases at present. Although effective screening and treatment can save lives to a certain extent, our knowledge of the disease is far from sufficient. KIF18B is a member of the kinesin-8 superfamily and plays a conserved regulatory role in the cell cycle. KIF18B reportedly functions as an oncogene in…[Read more]

1 mm, 9-29 mm) in 21 patients (male/female = 11/9; mean age ± SD 65.3 ± 7.4; age range 50-76 years). The average SUV

values ± SD of the benign and malignant nodules were 2.2 ± 1.7

. 7.0 ± 4.5, respectively (p = 0.0148). Average

values in benign and malignant nodules were 0.0057 ± 0.0071 and 0.0230 ± 0.0155 min

, respec…[Read more]

05). There were statistically significant differences in lymphopenia, increased C-reactive protein and abnormal chest CT between children and adult patients (P < 0.05). Twenty-seven families reported adults as first case of COVID-19 in family clusters.

The same virus strain can cause milder disease in children compared with their car…[Read more]

Time to positivity (TTP), calculated automatically in modern blood culture systems, is considered a proxy for microbial load and has been suggested as a potential prognostic marker in bloodstream infections. In this large, multicentre, prospectively collected cohort, our primary analysis aimed to quantify the relationship between the TTP of…[Read more]

hould not use the uninjured contralateral limb as a “healthy” reference, as it also exhibits mechanical differences compared with controls. Results could inform the development of neuromuscular and strength training programs targeting the restoration of knee biomechanics similar to healthy controls to prevent early-onset degeneration that is…[Read more]

Although cardiovascular comorbidities seem to be strongly associated with worse outcomes in patients with coronavirus disease 2019 (COVID-19), data regarding patients with preexisting heart failure are limited.

To investigate the incidence, characteristics and clinical outcomes of patients with COVID-19 with a history of heart failure with…[Read more]

Although cardiovascular comorbidities seem to be strongly associated with worse outcomes in patients with coronavirus disease 2019 (COVID-19), data regarding patients with preexisting heart failure are limited.

To investigate the incidence, characteristics and clinical outcomes of patients with COVID-19 with a history of heart failure with…[Read more]

Both discrepancy of the spatial distribution and principal component analysis indicated that sources of these organic pollutants may be related to the type of stores. Various construction and decoration materials might have been responsible for the high concentrations of OPEs and CPs, and thus, these materials require further analysis.Screening…[Read more]