Everett Rosa

Nevertheless, genetic evidence stemming from the use of engineered strains of mice has provided significant insight into the overlapping and complementary metabolic effects that physiological autophagy and the control of mTOR activity exert during fasting and nutrient overload.Cisplatin resistance is a challenge in the treatment of epithelial…[Read more]

Nevertheless, genetic evidence stemming from the use of engineered strains of mice has provided significant insight into the overlapping and complementary metabolic effects that physiological autophagy and the control of mTOR activity exert during fasting and nutrient overload.Cisplatin resistance is a challenge in the treatment of epithelial…[Read more]

Introduction Psoriasis is a common, chronic inflammatory skin condition that affects 2-3% of the US population and represents a large psychosocial burden for patients. Over the last decade, highly effective targeted therapies for psoriasis have been developed – namely, those targeting interleukin (IL)-17 and IL-23. The success of biologic agents…[Read more]

Children watching a cartoon made significantly stronger projections to non-human animals than children watching the documentary. Children’s projections to humans and inanimate objects did not differ between the groups and were uniformly low. One of the possible explanations of the results is in terms of children’s essentialist expectation that…[Read more]

Children watching a cartoon made significantly stronger projections to non-human animals than children watching the documentary. Children’s projections to humans and inanimate objects did not differ between the groups and were uniformly low. One of the possible explanations of the results is in terms of children’s essentialist expectation that…[Read more]

PCSK9 is secreted into the circulation, mainly by the liver, and interacts with low-density lipoprotein receptor (LDLR) homologous and non-homologous receptors, including CD36, thus favouring their intracellular degradation. As PCSK9 deficiency increases the expression of lipids and lipoprotein receptors, thus contributing to cellular lipid…[Read more]

PCSK9 is secreted into the circulation, mainly by the liver, and interacts with low-density lipoprotein receptor (LDLR) homologous and non-homologous receptors, including CD36, thus favouring their intracellular degradation. As PCSK9 deficiency increases the expression of lipids and lipoprotein receptors, thus contributing to cellular lipid…[Read more]

The incorporation of patient-reported outcomes with traditional disease risk classification was found to strengthen survival prediction in patients with myelodysplastic syndromes (MDS). In the present Canadian MDS registry analysis, we validate a recently reported prognostic model, the Fatigue-International Prognostic Scoring System among…[Read more]

Acute kidney injury (AKI) is a common clinical problem that is associated with high mortality due to multiple complex mechanisms. Cisplatin is the most important and highly effective chemotherapeutic agent used for the treatment of various solid tumors; however, it is associated with dose-dependent adverse effects, particularly in the kidney where…[Read more]

International guidelines define relapse prevention for schizophrenia patients as a key therapeutic aim. However, approximately 80% to 90% of schizophrenia patients experience further symptom exacerbation after the first episode. The purpose of this study was to investigate whether group integrated neurocognitive therapy (INT), a cognitive…[Read more]

mm Hg, because these recommendations differ from some other guidelines.Background Vancomycin is associated with nephrotoxicity and the mechanism may in part be related to oxidative stress. In vitro and preclinical studies suggest melatonin supplementation decreases oxidative stress. The objective of this study was to evaluate concomitant use of…[Read more]

This study demonstrates a simple and multistep approach for a covalent functionalization of chemically-prepared graphene oxide (GO) using branched polyethylenimine (PEI) through nucleophilic addition reaction to prepare GO-PEI. Further layer-by-layer (LBL) assembly on functionalized GO-PEI with anionic polyelectrolyte, poly(acrylic acid sodium…[Read more]

Increased use of mobile phones and social media platforms suggests mobile health technologies (mHealth) may present efficient platforms to deliver these interventions.

Findings are utilized to discuss low-cost interventions addressing the disparities in ANC uptake. Interventions should aim to enable vulnerable women to make informed decisions…[Read more]