Barry Cobb

Understanding the molecular basis of fibrosis, the lethal complication of COVID-19, is urgent. By the analysis of RNA-sequencing data of SARS-CoV-2-infected cells combined with data mining we identified genes involved in COVID-19 progression. To characterize their implication in the fibrosis development we established a correlation matrix based on…[Read more]

IM and dDAVP increased the intracellular cAMP levels and caused the AQP2 molecule to localize to the collecting duct cells’ luminal side. The urinary reabsorption mechanism through the bladder epithelium was not activated by anticholinergic administration. Thus, anticholinergics suppress urine production via an increase in urine reabsorption in…[Read more]

There has been an improvement in the LS in patients diagnosed with osteosarcoma over the last 15years. The development of metastasis during follow-up has reduced and the overall survival in the last 15years has improved. LS longer than 4weeks is associated with a poorer prognosis.

There has been an improvement in the LS in patients diagnosed…[Read more]

Moreover, the VDAC1-AKT (protein kinaseB)-GSK3β (glycogen synthase kinase 3 beta)-VDAC1 signaling pathway was abnormally activated in the hippocampus of APP/PS1 mice after noise exposure.

Chronic noise exposure and APP/PS1 overexpression may synergistically exacerbate cognitive impairment and neuropathological changes that occur in AD.…[Read more]