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Gade Tyson posted an update 6 months, 3 weeks ago
The 95 DDA-coated group exhibited higher ALP, Runx2, osteocalcin, and osteonectin expression compared to the 80 DDA and control groups on days 7 and 14. Conclusion A high DDA of chitosan promotes biomineralization and osteoblast formation. Therefore, this combination of laser surface and chitosan can enhance future dental implant healing processes and osseointegration.Induced pluripotent stem cells (iPSCs) hold a great potential for therapeutic regenerative medicine. The aim of this study was to generate induced pluripotent stem cells from goat embryonic cardiac tissue derived fibroblasts. Rapamycin The isolated cardiac fibroblasts from the cardiac tissue of goat embryos were positive for alfa smooth muscle actin, vimentin and discoidin domain receptor2. From these cells, we generated transgene free iPSCs using piggyBac transposons / transposase using five transcription factors (Oct4, Sox2, Klf, Myc and Lin 28). The generated iPSCs were SSEA1, SSEA4 and Oct4 positive. They were cultured on neofeeders using 20% Serum replacement – IMDM with bFGF. They could form cystic and compact embryoid bodies that showed differentiated ectodermal and mesodermal like cells when cultured using 20% FBS-IMDM without bFGF. The iPSCs, generated in the frame of this approach were produced without the use of integrating virus and the reprogramming transgenes were removed at the end of the process. Though there were limitations in the approach used, a substantial sign of reprogramming was obtained.Smoking cigarettes is a leading global cause of preventable death and disease. Men historically smoke more than women, but the prevalence of smoking among women in low and middle-income countries is increasing at an alarming rate. Understanding the factors that influence smoking initiation among women and girls is needed to address the growing epidemic of women smokers and the looming impact on women’s health worldwide. We assume that smoking initiation is embedded in socio-culturally influenced gendered context and use a social cognitive model with a gendered lens as a framework for organizing and synthesizing the research. Guided by this framework, we identified gaps in the literature and make recommendations for future research in this review paper. The results suggest that psychological and environmental determinants are rooted in fluctuating cultural influences and values, but few research studies provide a gendered analysis or systematically examine these factors in the context of gender and culture. Sex/gender is a significant construct through which women and girls experience the psychological, environmental, and other influences on smoking initiation. Much more research is needed to understand the psychological and environmental influences as well as the intersection of gender roles and other social categories on female smoking initiation.Bench-scale experiments were conducted to investigate the effect of hydraulic loadings and influent concentration on the migration and biotransformation behavior of three groundwater pollutants ammonium (NH4+), iron (Fe2+) and manganese (Mn2+). Columns packed with aquifer media collected from a river bank filtration (RBF) site in Harbin City, NE China were introduced synthetic groundwater (SGW) or real groundwater (RGW) were at two different constant flow rates and initial contaminant concentrations to determine the impact of system conditions on the fate of the target pollutants biotransformation. The results showed that the biotransformation rate of Fe2+ Mn2+, and NH4+ decreased by 8%, 39% and 15% under high flow rate (50 L d-1) compared to low flow rate (25 L d-1), which was consistent with the residence-time effect. While the biotransformation rate of Fe2+ Mn2+, and NH4+ decreased by 7%, 14% and 9% under high influent concentration compared to original groundwater. The 16S rRNA analysis of the aquifer medlts should improve understanding of the transport and fate of common groundwater pollutants in riverbank filtration and other groundwater recharge environments.We employ physics-informed neural networks (PINNs) to infer properties of biological materials using synthetic data. In particular, we successfully apply PINNs on inferring permeability and viscoelastic modulus from thrombus deformation data, which can be described by the fourth-order Cahn-Hilliard and Navier-Stokes Equations. In PINNs, the partial differential equations are encoded into a loss function, where partial derivatives can be obtained through automatic differentiation (AD). In addition to tackling the challenge of calculating the fourth-order derivative in the Cahn-Hilliard equation with AD, we introduce an auxiliary network along with the main neural network to approximate the second-derivative of the energy potential term. Our model can simultaneously predict unknown material parameters and velocity, pressure, and deformation gradient fields by merely training with partial information among all data, i.e., phase field and pressure measurements, while remaining highly flexible in sampling within the spatio-temporal domain for data acquisition. We validate our model by numerical solutions from the spectral/hp element method (SEM) and demonstrate its robustness by training it with noisy measurements. Our results show that PINNs can infer the material properties from noisy synthetic data, and thus they have great potential for inferring these properties from experimental multi-modality and multi-fidelity data.
This brief study examines race/ethnic differences in geographic distance to mothers among adults in the U.S.
Race/ethnic differences in rates of adult children living with their mothers in the U.S. are well documented but spatial distances beyond shared housing are not.
Spatial distances between residential locations of adults 25 and older and their biological mothers are estimated using the 2013 Panel Study of Income Dynamics for Hispanics, blacks, and whites. Multinomial logistic regression models and nonlinear decomposition techniques are used to assess the role of demographic factors, socioeconomic status, and health of the child and mother in accounting for race/ethnic differences in adult child-mother proximity.
Blacks are more likely than whites to live with their mother and more likely to live within 30 miles but not coresident, whereas whites are more likely to live more than 500 miles away. Geographic proximity to mother is distinct for Hispanics with nearly one-third having their mother outside the U.
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