Pritchard Pagh

Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, the immunosuppressive factors induced by radiation on tumor cells remain to be identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast cancer (BC) cells and RT-treated mouse syngeneic…[Read more]

Finally, the possible development directions and challenges of mesoporous nanomaterials for electrochemical energy conversion and storage are proposed.

A nationwide prospective drug utilization review (DUR) for potentially inappropriate medications (PIMs) in older adults was implemented in October 2015 in South Korea. We aimed to evaluate the…[Read more]

Dome-shaped macula is a relatively new entity, which has been mainly described in highly myopic adults. Since its description, an increasing number of studies have been published to help characterise this condition and to elucidate its nature, causes, epidemiology and associated findings. Although the majority of the available data relate to…[Read more]

This study investigated the Pb(II) and Cd(II) sorption from aqueous solution by oily sludge-derived char (OSDC) prepared at different pyrolysis temperatures and chemical activation. The maximum Pb(II) sorption capacity for OSDC at pyrolysis temperature of 500 °C (OS500) was found as 351.48 mg/g, which was greater than that of OSDC produced at…[Read more]

G only presented higher percent rapid-eye-movement sleep and lower daytime sleepiness compared to the MDG (both P<0.05). Results were similar in the per-protocol analysis (n=127).

A dietary/lifestyle intervention on top of standard care leads to greater improvements in OSA severity and symptomatology compared to standard care alone.…[Read more]

In Reversed-Phase Liquid Chromatography, Quantitative Structure-Retention Relationship (QSRR) models for retention prediction of peptides can be built, starting from large sets of theoretical molecular descriptors. Good predictive QSRR models can be obtained after selecting the most informative descriptors. Reliable retention prediction may be an…[Read more]

In recent years, the development and implementation of animal-free approaches to chemical and pharmaceutical hazard and risk assessment has taken off. Alternative approaches are being developed starting from the perspective of human biology and physiology. Neural tube closure is a vital step that occurs early in human development. Correct closure…[Read more]

These included a requirement for reference standards for potency, better characterisation of applicability domains/technical limitations of NAMs, development of a framework for weight of evidence assessments, and an increased confidence in the characterisation of non-sensitisers. Finally, exploration of an industry/regulator cross-sector…[Read more]

The incorporation of a TP fluorophore into the nanoprobe facilitated near-infrared excitation, which allowed the highly sensitive and specific imaging of Zn2+ in living cells and tissues at greater depths than possible previously. The TP-DNAzyme-MOFs nanoprobe achieved a low detection limit of 3.53 nM, extraordinary selectivity toward Zn2+, and a…[Read more]

A 67-year old woman with a history of long-term Chinese herb use was admitted to our institution complaining of abdominal pain. Barium enema disclosed rigidity of throughout the proximal colon and a slightly elevated lesion in the transverse colon. Colonoscopy showed diffuse and bronze mucosa in the proximal colon, which was compatible with…[Read more]

Cell-type enrichment analysis of the transcriptomes showed that immune cells, including macrophages and granulocytes, were enriched in both infection groups. Collectively, our study profiled the transcriptomic response of chicken lungs infected with P. multocida and provided valuable information to understand the chicken responses to P. multocida…[Read more]