Franklin Stafford

The self-renewal transcription factor Nanog and the phosphoinositide 3-kinase (PI3K)-Akt pathway are known to be essential for maintenance of mesenchymal stem cells. We evaluated their contribution to the maintenance of CD133(+) cancer stem-like cells (CSCs) and spheroid-forming cells in patient-derived cell lines from three human sarcoma subtypes…[Read more]

OBJECTIVE To investigate the association between non-high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio and degree of coronary artery stenosis proven by coronary angiography. METHODS A total of 1867 patients were enrolled into this study and analyzed retrospectively. Three hundred…[Read more]

Given their strong affinity for the skeleton, trace elements are often stored in bones and teeth long term. Diet, geography, health, disease, social status, activity, and occupation are some factors which may cause differential exposure to, and uptake of, trace elements, theoretically introducing variability in their concentrations and/or ratios…[Read more]

The tests can be useful as intermediate resolution typing for solid organ transplantation.

Lymphoma is a malignancy of hematopoietic and lymphoid tissues. Early diagnosis of lymphoma is very important and could save patients’ lives. Nevertheless, the diagnosis of lymphoma could be difficult in the presence of complex manifestations and a lack…[Read more]

The use of natural antimicrobial peptides (AMPs) is limited. Modifications of peptides by in silico predictions and computational methods can lead to more accurate designs and reducing their high synthesis costs, instability, and cytotoxicity. In this study, the antifungal properties of CecropinA-Magenin2 (CE-MA) hybrid peptide and its truncated…[Read more]

3% and 75.0% in Period 1 and 2 respectively. Decrease in weight-for-height percentile during treatment and central nervous system tumors are significant predictors of a less favorable survival. Malnutrition risk screening and intensified nutrition therapy have positive effects on nutritional status and therefore patient survival in pediatric…[Read more]

18F-FDG PET/CT imaging showed that stressed RBCs were mainly trapped in spleen, while untreated RBCs remained in circulation system. Thus, stressed RBCs can be effectively labelled by 18F-FDG and tend to be trapped in spleen of mice as assessed by PET/CT.This study investigated a novel agricultural low-cost bio-waste biochar derived from wood…[Read more]

Understanding of the functions of enzymes in diverse cellular processes is important, but the design of sensors with controllable localization for in situ imaging of subcellular levels of enzymatic activity is particularly challenging. We introduce herein a spatiotemporally controlled sensor technology that permits in situ localization and…[Read more]

The electrochemical utilization of organic electrode materials (OEMs) is highly dependent on an excess amount of inactive carbon at the expense of low packing density and energy density. In this work, the challenges by substituting inactive carbon with electronic conductive inorganic cathode (ECIC) materials, which are endowed with high electronic…[Read more]

Spinal cord injury (SCI) causes intractable disease and leads to inevitable physical, financial, and psychological burdens on patients and their families. SCI is commonly divided into primary and secondary injury. Primary injury occurs upon direct impact to the spinal cord, which leads to cell necrosis, axon disruption, and vascular loss. This…[Read more]