• 2% of cases. The study identified specific factors associated with lower consistency and accuracy.

    Diagnosis was highly consistent across time and moderately between examiners. Accuracy was almost perfect for stage and moderate for grade and extent. Additional efforts are required to improve training of general dentists.

    Diagnosis was…[Read more]

  • The best enzyme activity enhancement was obtained for the same nonavalent compound, which increased 5.2-fold the activity of the misfolded enzyme at 2.5 μM, what constitutes the first example of a multivalent α-Gal A activity enhancer of potential interest in the treatment of Fabry disease. A series of tripeptidic proteasome inhibitors with f…[Read more]

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