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Crosby Dalton posted an update 6 months, 3 weeks ago
INTRODUCTION The consumption of certain foods and healthy eating habits are related to preventing and suffering from a number of chronic diseases. These foods tend to be included in food pyramids, such as that proposed by the Spanish Society for Community Nutrition. One method of analysing diet quality is the use of indices that assess the frequency of consumption of different food groups. AIM To analyse diet quality in a Spanish population of persons aged over 65years using the Healthy Eating Index and to determine how sociodemographic factors affect scores on the index. DESIGN A cross-sectional, descriptive study was conducted on the diet followed at home by Spanish population aged over 65years, using the Healthy Eating Index and taking information from the 2014 European Health Interview Survey in Spain. Multiple linear regression analysis was used to determine the socioeconomic factors associated with diet quality. RESULTS Of the study population, 89.6% need to make changes in their diet, while only 8.2% follow a healthy diet. Suffering from chronic diseases, overweight and occasional physical exercise were associated with higher scores on the Healthy Eating Index. CONCLUSION Most of the population aged 65years or over need to make changes in their dietary patterns. Those with potential health risks are more careful about their diet. These findings confirm the need to promote guidelines for healthy eating in the non-clinical population. L.U.The “insomnia complaint” currently has a very high prevalence in the medical consulting room. This assumes that any doctor must have some basic notions of how to approach it. But currently, there are certain aspects that hinder this approach, especially when the “insomnia disorder” needs to be ruled out from the rest of the primary sleep disorders. This article aims to break with the terminological confusion that encompasses the concept of “insomnia”, providing the definitions of the most correct terms to use. This will provide us with good tools for the correct collection of information, which will be of great help for the application of a clinical diagnostic algorithm of “Chronic adult Insomnia disorder”. This will be able to differentiate it mainly from the rest of primary sleep disorders, and thus, apply a specific treatment, which will resolved on the basis of the “insomnia complaint” by the patient. L.U.BACKGROUND Rearranged during transfection (RET) proto-oncogene gene fusions are rare in non-small-cell lung cancer (NSCLC). We compared the efficacy of pemetrexed-based chemotherapy with other chemotherapy regimens in patients with NSCLC with different RET fusion subtypes. PATIENTS AND METHODS A retrospective, multicenter study of patients with pathologically confirmed stage IIIB/IV lung adenocarcinomas was conducted. RET rearrangements were detected using next generation sequencing. We analyzed the clinical characteristics of patients with RET-rearranged NSCLC and the efficacy of chemotherapy regimens. We also evaluated the efficacy between groups of patients with and without KIF5B-RET-rearranged lung cancer. RESULTS We evaluated 62 patients with NSCLC and RET rearrangements, including 41 with KIF5B-RET, 15 with CCDC6-RET, and 6 with other rare fusion subtypes. Of these 62 patients, 50 had stage IIIB/IV. We also evaluated 40 patients with first-line chemotherapy information available. The median progression-or patients with NSCLC and RET rearrangements. INTRODUCTION The Hoosier Cancer Research Network (HCRN) LUN 14-179 is a phase II trial of consolidation pembrolizumab after concurrent chemoradiation for the treatment of patients with stage III non-small-cell lung cancer (NSCLC). Time to metastatic disease or death (TMDD), progression-free survival (PFS), and overall survival (OS) appear to be superior to that in historical controls of chemoradiation alone. Unfortunately, not all patients benefit from consolidation immunotherapy. We performed a univariate analysis to evaluate variables associated with PFS, metastatic disease, and OS. PATIENTS AND METHODS We conducted a retrospective analysis of patients enrolled in HCRN LUN 14-179. Data collected included age, sex, stage, smoking status, programmed death ligand 1 status, Grade (G) ≥ 2 versus G ≤ 1 adverse event, G ≤ 2 versus G ≥ 3 pneumonitis, duration of pembrolizumab ( less then 4 vs. ≥ 4 cycles), chemotherapy regimen, performance status 0 versus 1, time to start pembrolizumab (4-6 vs. 6-8 weeks from radiation), volume of lung receiving at least 20 Gy of radiation (V20; less then 20% vs. ≥ 20%). Capsazepine Univariable Cox regression was performed to determine the variables associated with 3 end points TMDD, PFS, and OS. RESULTS From April 2015 to December 2016, 93 patients were enrolled and 92 were included in the efficacy analysis (1 patient was ineligible). For TMDD, improved outcomes might be associated (P less then .1) with stage IIIA and ≥ 4 cycles of pembrolizumab. For PFS, improved outcomes (P less then .1) might be seen for ≥ 4 cycles of pembrolizumab, stage IIIA and V20 less then 20%. For OS, improved outcomes (P less then .1) might be seen for stage IIIA and ≥ 4 cycles of pembrolizumab. CONCLUSION Stage IIIA and longer duration of pembrolizumab treatment might be associated with prolonged TMDD, PFS, and OS for patients with stage III NSCLC treated with chemoradiation followed by pembrolizumab. BACKGROUND Poppers (i.e., alkyl nitrites) are commonly used during sex by gay, bisexual, and other men who have sex with men (sexual minority men). Poppers act as vasodilators when inhaled, resulting in a sensation some users refer to as a ‘head rush’, while also relaxing smooth muscles and facilitating penetration during anal sex. In 2013, Health Canada initiated a crackdown on poppers products. The current study aims to examine the experiences and perspectives of young sexual minority men who use poppers in the context of the federal crackdown. METHODS We draw on 50 semi-structured, in-depth interviews collected from 2018 to 2019 in Vancouver with sexual minority men ages 15-30. We used a combination of both inductive and deductive techniques during data analysis to identify several key themes. RESULTS Participants’ discussions reflected positive effects of poppers use relating to sexual pleasure and bodily control. Participants used poppers to enhance pleasure, reduce pain and injury (e.g., from tears in anal tissue), and improve their capacity to “let go” and enjoy sex.
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