Riggs Washington

Pembrolizumab single dose half-life following 2 mg/kg, 10 mg/kg, and 200 mg was 15.1, 15.8, and 12.3 days, respectively. Serum exposure at the doses studied (range, 2-10 mg/kg) was approximately linear; steady-state area under the curve0-21 days (95% confidence interval ) was 730.9 (627.4-851.6), 2,819.2 (2,009.4-3,955.4), and 931.0 (72…[Read more]

Physicians should improve the setting, share knowledge in all clarity, involve the patients in further planning, and consider demographical variables. PRACTICE IMPLICATIONS Using SPIKES as a framework can optimize breaking bad news conversations but it seems important to emphasize the individual preferences beyond the six steps and tailor the…[Read more]

Hypernatremia is common in critical care, especially in severely burned patients. Its occurrence has been linked to increased mortality. Causes of hypernatremia involve a net gain of sodium or a loss of free water. Renal loss of electrolyte-free water due to urea-induced osmotic diuresis has been described as causative in up to 10% of…[Read more]

The Journal of Comparative Psychology has enjoyed a century of publishing some of the best investigations of animal behavior, often with reference to human cognition and behavior. This long history has manifested many paradigm-like shifts. Researchers have fluctuated between treating animals as models of human learning to emphasizing stark…[Read more]

BACKGROUND There continues to be a disjoint between the emergence of new diagnostic technologies and venues to train new physicians on how to apply them. Next-generation sequencing (NGS) has become a very important tool for a wide range of clinical applications. Technical complexity and cost have been the major obstacles in incorporating these…[Read more]

CONCLUSIONS Preoperative BPV predicts postoperative outcomes. BPV should be considered in individualized risk assessment and subgroup risk stratification. AIM To compare the efficacy of Negative Pressure Wound Therapy (NPWT) with and without irrigation with 0.1% polyhexanide-betaine. METHODS We randomized 150 subjects in a 16-week RCT to compare…[Read more]

BACKGROUND Maternal mortality is high in Loreto, Peru, but can be reduced by high quality antenatal care. Indicators for the quality of antenatal care received include the timing (with respect to gestational age) and number of antenatal appointments attended, the delivery of antenatal services and health information, and women’s perceptions about…[Read more]