Collins Navarro

Several years ago, the crystallographic structures of the transient receptor potential vanilloid 1 (TRPV1) in the presence of agonists and antagonists were reported, providing structural information about its chemical activation and inactivation. TRPV1’s activation increases the transport of calcium and sodium ions, leading to the excitation of…[Read more]

Hydrochars are materials with a promising future, as their high carbon content and porosity renders them suitable for uses including peat substitutes, soil remediation and carbon adsorbent precursors. Combining hydrothermal carbonization and pyrolysis offers the prospect to provide advanced materials with a higher porosity and carbon content. This…[Read more]

The current chemotherapy agents against various forms of leishmaniasis have some problems and side effects, including high toxicity, high cost, and the emergence of resistant strains. Here, we aimed to review the preclinical studies (in vitro and in vivo) on the anti-leishmanial activity of chitosan and chitosan-based particles against…[Read more]

While all vitamin D-treated PBMCs showed reduced levels of IFN-γ production, in vitro treatment of vitamin D showed no influence in IL-10 production. EBV and vitamin D were found to exert opposite in vitro effects on immune dysregulation in these patients. Our results highlight the complex interactions of different risk factors with immune…[Read more]

Identity analysis further reveals that hate in the US initially targets political figures, then grows predominantly racially charged; in the Philippines, targets of hate consistently remain political over time. Finally, we demonstrate that higher levels of community hate are consistently associated with smaller, more isolated, and highly…[Read more]