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Linnet Gammelgaard posted an update 6 months, 3 weeks ago
Active neck musculature plays an important role in the response of the head and neck during impact and can affect the risk of injury. Finite element Human Body Models (HBM) have been proposed with open and closed-loop controllers for activation of muscle forces; however, controllers are often calibrated to specific experimental loading cases, without considering the intrinsic role of physiologic muscle reflex mechanisms under different loading conditions. This study aimed to develop a single closed-loop controller for neck muscle activation in a contemporary male HBM based on known reflex mechanisms and assess how this approach compared to current open-loop controllers across a range of impact directions and severities. Controller parameters were optimized using volunteer data and independently assessed across twelve impact conditions. The kinematics from the closed-loop controller simulations showed good average CORA rating to the experimental data (0.699) for the impacts following the ISO/TR9790 standard. Compared to previously optimized open-loop activation strategy, the average difference was less than 9%. The incorporation of the reflex mechanisms using a closed-loop controller can provide robust performance for a range of impact directions and severities, which is critical to improving HBM response under a larger spectrum of automotive impact simulations.Timely and efficient removal of xenobiotics and metabolites from the brain is crucial in maintaining the homeostasis and normal function of the brain. The choroid plexus (CP) forms the blood-cerebrospinal fluid barrier and vitally removes drugs and wastes from the brain through several co-existing clearance mechanisms. The CP epithelial (CPE) cells synthesize and secrete the cerebrospinal fluid (CSF). As the CSF passes through the ventricular and subarachnoid spaces and eventually drains into the general circulation, it collects and removes drugs, toxins, and metabolic wastes from the brain. This bulk flow of the CSF serves as a default and non-selective pathway for the removal of solutes and macromolecules from the brain interstitium. Besides clearance by CSF bulk flow, the CPE cells express several multispecific membrane transporters to actively transport substrates from the CSF side into the blood side. ABBV-075 mw In addition, several phase I and II drug-metabolizing enzymes are expressed in the CPE cells, which enzymatically inactivate a broad spectrum of reactive or toxic substances. This review summarizes our current knowledge of the functional characteristics and key contributors to the various clearance pathways in the CP-CSF system, overviewing recent developments in our understanding of CSF flow dynamics and the functional roles of CP uptake and efflux transporters in influencing CSF drug concentrations.We calculated the adsorption of H, O, OH, and H2O and the dissociation of H2O molecule on the Cu(111), Cu(100), and Cu(110) surfaces using density functional theory. H, O, and OH tend to adsorb stably at the highly coordinated dh and h sites on the Cu(111) and Cu(100) surfaces. OH and H tend to adsorb on sb site on the Cu(110) surface. The more charge transfer of the adsorbed substance, the more stable the adsorption. The dissociation product is O+H on the Cu(111) surface, while the dissociation product is OH+H on the Cu(100) and Cu(110) surfaces. Due to the different geometric structures of initial state (IS), transition state (TS), and final state (FS) in the dissociation reaction, the dissociation of water on the copper surface does not establish a linear Brønsted-Evans-Polanyi (BEP) relationship. These results provide theoretical support for the understanding of the interaction between water and metals as well as the behavior of water molecules.Romantic relationships are changing in Western culture. The recent rise of alternative relationship models called consensual non-monogamies (CNMs) has drawn attention toward them. Western cultures largely stereotype and stigmatize CNMs, portraying their practitioners (among other aspects) as psychologically distinct from monogamous practitioners. Likewise, recent scientific literature suggests probable differences for CNMs practitioners, mainly them being more extraverted, agreeable, and open, but also less jealous and dominant toward their romantic partners. However, although CNMs differentiate themselves from cheating monogamous practitioners, potential differences are unclear. The present study compared 372 participants (with 193 CNMs practitioners) from Spanish culture regarding their personality, sexual satisfaction, dominance, and jealousy. On most dimensions, monogamous and CNMs practitioners did not differ significantly from each other. CNMs practitioners showed significantly higher openness and lower conscientiousness, although these differences were small and debatable; thus, these findings should be taken with caution. These differences could not be explained by differences in age, gender, education, marital status, sexual orientation, or other demographic variables. The addition of cheating monogamous mitigated these differences. Overall, this study suggests that monogamous and non-monogamous practitioners are not psychologically different. Methodological limitations and future recommendations are discussed, with particular emphasis on replication studies.In the U.S., human papillomavirus (HPV) vaccination has been recommended for individuals up to age 26, although the vaccination is currently approved for all people up to the age of 45. This research sought to explore HPV vaccination disparities by age with subgroup analysis by gender identity and sexual orientation groups, as well as sociodemographic factors that may serve as barriers to or facilitators of vaccination. This study used data from the 2018 Behavioral Risk Factor Surveillance System. Only data for individuals who reported their gender identity, sexual orientation, and HPV vaccination status were included in the analytic sample (n = 7330). HPV vaccination rates for this sample were low, as only 18.2% (n = 1332) of the sample had received the HPV vaccination. These low rates of vaccination were similar across all subsamples cisgender men (9.8%, n = 343), cisgender women (25.8%, n = 985), heterosexuals (17.5%, n = 1197), lesbian women or gay men (20.8%, n = 40), and bisexuals (30.8%, n = 95). In multivariable logistic regression models, younger participants (18-34) were more likely to report receiving the HPV vaccination across all subsamples.
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