Devine Sinclair

BACKGROUND The effectiveness of trunk restraint on post-stroke arm motor function and daily function remain controversial. OBJECTIVE To evaluate the effect of adding trunk restraint to task-oriented rehabilitation of arm motor function and functional ability after stroke. METHODS Nine databases were systematically searched for randomized…[Read more]

Delusions are a difficult-to-treat and intellectually fascinating aspect of many psychiatric illnesses. Although scientific progress on this complex topic has been challenging, some recent advances focus on dysfunction in neural circuits, specifically in those involving dopaminergic and glutamatergic neurotransmission. Here we review the role of…[Read more]

Factors identified could be grouped into four themes-therapy-related, patient-related, healthcare provider-related, and health system-related. Key barriers to optimal OAC management were mostly patient-related, whereas interventions focused on education or implementing protocols were shown through RCTs to be effective at improving knowledge scores…[Read more]

Aspergillus spp. infections remain a global concern, with ∼30% attributable mortality of invasive aspergillosis (IA). VT-1598 is a novel fungal CYP51 inhibitor designed for exquisite selectivity versus human CYP enzymes to achieve a maximal therapeutic index and therefore maximal antifungal efficacy. Previously, its broad-spectrum in vitro a…[Read more]

ffectively prevented CNV and microglial infiltration. CONCLUSIONS Our findings suggest that the novel CCBs identified here are effective anti-inflammatory agents that can be further evaluated for treating NV disorders and can be potentially applied in the treatment of ocular inflammatory and pathological angiogenetic disorders.BACKGROUND The…[Read more]

Context Managing the care of an increasing and ageing prisoner population, including providing palliative and end of life care, is a challenge worldwide. There is little known about the views of health professionals who provide palliative care to hospitalised prisoner patients. Objectives To explore experiences and perspectives of health…[Read more]

Edible fungi residues are natural fungi etching feedstock that provide loose structure with multidimensional framework. These advantages help KOH to penetrate rigid cytoderm into innermost space and attain porous carbon with high porosity. Utilization of edible fungi residue not only avoids artificial operation of fungal inoculation and culture…[Read more]

Deformities of bones of the face and extremities are markers of leprosy (Hansen’s disease) which contribute to stigma associated with this disease. Among these deformities are articular alterations that can mimic rheumatoid arthritis (RA). In this case, a 64-year-old man presented with a history of having been treated for lepromatous leprosy and…[Read more]