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Mccall Vinding posted an update 7 months, 4 weeks ago
The most potent derivatives 7a, 7b, 7c, 8c and 10c were tested for their cytotoxicity against normal VERO cell lines. Compounds 7a, 7b, 7c, 8c and 10c are respectively, 2.41, 4.85, 4.08, 3.23 and 5.89 fold times more toxic in HCT116 than in VERO normal cells. Moreover, the most active anti-proliferative derivatives 7a, 7b, 7c, 8c and 10c were…[Read more]
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Lloyd Tanner posted an update 7 months, 4 weeks ago
It was generally believed that weak van der Waals interactions exist between neighboring layers in the two-dimensional group-IV chalcogenides. Using PbSe as a prototypal example, we find additional strong coupling between the Pb-Pb layers, as evidenced by detailed analysis of the differential charge density plot. The coupling is covalent-like and…[Read more]
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Leach Sparks posted an update 7 months, 4 weeks ago
The best policy to follow when nursing homes are massively hit by SARS-CoV2 is unclear.
To describe COVID-19 containment in a nursing home transformed into a caring center.
Physicians and nurses were recruited. The facility was reorganized and connected with the laboratory of the reference hospital. Ultrasound was used to diagnose…[Read more]
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Osborn Fulton posted an update 7 months, 4 weeks ago
Our results suggested that P. minutus’ ability to alter the host’s behaviour may have evolved to specifically target sympatric gammarid host species. Uninfected gammarids did not appear to avoid the non-host predator chemical cues. Overall the results also opened the possibility that parasites may play a critical role in the success or failure of…[Read more]
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Saunders Roth posted an update 7 months, 4 weeks ago
This study aimed to determine whether coronary artery calcium score (CACS) can be a prognostic indicator for the development of major adverse cardiac events (MACEs) and compare the value of CACS with that of the 123I-betamethyl-p-iodophenyl-pentadecanoic acid (123I-BMIPP) defect score (BDS) in patients with non-ischemic heart failure with…[Read more]
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Karlsson Andrews posted an update 7 months, 4 weeks ago
Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor that limits excessive T cell responses. Cancer cells have evolved to evade these immunoregulatory mechanisms by upregulating PD-1 ligands and preventing T cell-mediated anti-tumor responses. Consequently, therapeutic blockade of PD-1 enhances T cell-mediated anti-tumor…[Read more]
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Lloyd Lykke posted an update 7 months, 4 weeks ago
These had binding constants with uptake sites very similar to that of Gd (KNd, Y, Tm, Eu = 107.0). Our results suggest that the different REE likely share common transport sites and that the biotic ligand model (BLM) can be used to predict their uptake.Cardiovascular events can occur after deferred revascularization, and mal…[Read more]
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Copeland Wollesen posted an update 7 months, 4 weeks ago
Graphical Abstract.Hepatic encephalopathy (HE) may occur in patients with liver failure. The most critical pathophysiologic mechanism of HE is cerebral edema following systemic hyperammonemia. The dysfunctional liver cannot eliminate circulatory ammonia, so its plasma and brain levels rise sharply. Astrocytes, the only cells that are responsible…[Read more]
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Morales Tanner posted an update 7 months, 4 weeks ago
Social insects establish complex interactions with microorganisms, some of which play defensive roles in colony protection. The important role of pollinators such as the stingless bee Melipona scutellaris in nature encouraged us to pursue efforts to study its associated microbiota. Here we describe the discovery of two novel cyclic…[Read more]
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Browne Mitchell posted an update 7 months, 4 weeks ago
A new Combination 3 dimensional Supermolecular Denver colorado Dexterity Polymer-bonded Together with Risk of Carbon Adsorption, Medicinal Task, and also Selective Feeling regarding Fe3+/Cr3+ Ions as well as TNP.
Water extract AMPW exhibited about 80% growth inhibition at 50% dilution. Since fruit pulp is the one consumed, the extracts AMPM…[Read more]
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Ware Kinney posted an update 7 months, 4 weeks ago
On the neural level, this inverse relationship between empathic disposition and self-other distinction performance was linked to a reduction of cTBS-induced rSMG activity in persons with lower dispositional empathy, and an increase in those with higher dispositional empathy. These two opposite impacts of cTBS were associated with two anatomically…[Read more]
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Faber Connell posted an update 7 months, 4 weeks ago
Compared with the 9 h group, the mRNA and protein expression of HO-1 were increased in dose-dependent manner in the 3 μM RES, 10 μM RES and 30 μM RES group. Compared with the 9 h group, rat myocardial injury was gradually alleviated in 3 μM RES, 10 μM RES and 30 μM RES groups. However, the rat myocardial injury in the 100 μM RES group showed…[Read more]
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Emerson Purcell posted an update 7 months, 4 weeks ago
me development, findings are shared to promote dissemination into other settings.
Public health emergencies and crises such as the current COVID-19 pandemic can accelerate innovation and place renewed focus on the value of health interventions. Capturing important lessons learnt, both positive and negative, is vital. We aimed to document the…[Read more]
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Koefoed Stone posted an update 7 months, 4 weeks ago
BACKGROUND Therapeutic plasma exchange (TPE) has been recommended by guidelines for the treatment of anti-neutrophil cytoplasmic antibodies-associated vasculitis (AAV) with severe kidney dysfunction. In recent years, some researchers have proposed that double-filtration plasmapheresis (DFPP) can also be used effectively in the treatment of these…[Read more]
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Hurley Lowry posted an update 7 months, 4 weeks ago
gondii strains from monkeys is summarized.
Recent data have challenged the historical paradigm that cystic fibrosis (CF) protects against otitis media (OM). These findings raised questions about the pathogenesis of this ostensible change. In this study our aim is to characterize acute OM (AOM) risk based on CF genotype.
A retrospective…[Read more]
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Rode McMahan posted an update 7 months, 4 weeks ago
fumigatus to ITC by scavenging reactive oxygen species (ROS) at a moderate concentration and promoting the production of ROS at a high concentration rather than regulating drug transport. Moreover, inhibition of polyamine biosynthesis reduced the intracellular polyamine content, resulted in accumulation of ROS and enhanced the antifungal activity…[Read more]
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Everett Rosa posted an update 7 months, 4 weeks ago
Introduction Psoriasis is a common, chronic inflammatory skin condition that affects 2-3% of the US population and represents a large psychosocial burden for patients. Over the last decade, highly effective targeted therapies for psoriasis have been developed – namely, those targeting interleukin (IL)-17 and IL-23. The success of biologic agents…[Read more]
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Bonner Mikkelsen posted an update 7 months, 4 weeks ago
In this paper, we focus on the problem of locating a scuba diver in distress using a sensor network. Without GPS reception, submerged divers in distress will transmit SOS messages using underwater acoustic communication. The study goal is to enable the quick and reliable location of a diver in distress by his fellow scuba divers. To this purpose,…[Read more]
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Bartlett Byrne posted an update 7 months, 4 weeks ago
5%, which is lower than the average COVID‑19 fatality rate in other European countries. The risk of in‑hospital death was associated with sex, age, and the number of coexisting diseases, such as chronic cardiovascular and respiratory diseases.
The estimated in‑hospital fatality rate for COVID‑19 was 11.5%, which is lower than the average…[Read more]
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McFadden Connell posted an update 7 months, 4 weeks ago
Endothelial cell (EC) dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy, and the angiotensin-converting enzyme 2 (ACE2) receptor plays a role in EC dysfunction in COVID-19. To expand the understanding of the role of the ACE2 receptor relative to EC dysfunction, this review addresses (1) tissue distribution of…[Read more]
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