• Compared with the 9 h group, the mRNA and protein expression of HO-1 were increased in dose-dependent manner in the 3 μM RES, 10 μM RES and 30 μM RES group. Compared with the 9 h group, rat myocardial injury was gradually alleviated in 3 μM RES, 10 μM RES and 30 μM RES groups. However, the rat myocardial injury in the 100 μM RES group showed…[Read more]

  • Purpose Imaging-based metrics for analysis of biological tissues are powerful tools that can extract information such as shape, size, periodicity, and many other features to assess the requested qualities of a tissue. Muscular and osseous tissues consist of periodic structures that are directly related to their function, and so analysis of these…[Read more]

  • Cancer incidence is rising, and accurate prediction of incident cancers could be relevant to understanding and reducing cancer incidence. The aim of this study was to develop machine learning (ML) models that could predict an incident diagnosis of cancer. Participants without any history of cancer within the Lifelines population-based cohort were…[Read more]

  • Additional studies will have to be carried out to determine whether this unique inhibition mechanism can occur at the cell surface.Competitive inhibitors of galactocerebrosidase (GALC) could be candidates for pharmacological chaperone therapy of patients with Krabbe disease. The known and selective nortropane-type iminosugar galacto-noeurostegine…[Read more]

  • The complete mitochondrial genome sequence of the Icefish, Chionobathyscus dewitti was determined by the Next Generation Sequencing (NGS) analysis. The complete mitogenome was 17,452 bp in length, which encoded the canonical 13 protein-coding genes, 22 tRNAs, two rRNAs, and two non-coding regions. As shown in the other notothenids, translocation o…[Read more]

  • t of age-associated changes to immunity.A combination of decision tree (DT) and fuzzy logic techniques was used to develop a fuzzy model for differentiating peanut plant from weeds. Color features and wavelet-based texture features were extracted from images of peanut plant and its three common weeds. Two feature selection techniques namely…[Read more]

  • Lesions were classified as stiff in 91 cases and soft in 35 (kappa coefficient=0.932). The ratio of stiff to soft lesions was significantly higher in PC than in non-PC (623 vs. 2932, P<0.001). The sensitivity, specificity, and negative predictive value of a stiff lesion with vs. without MPDD for diagnosis of PC were 94%, 23%, and 50% vs. 100%,…[Read more]

  • Rouse Lu posted an update 7 months, 4 weeks ago

    Bone imbalance between anabolic and catabolic processes at the level of remodeling unit due to the prevalence of resorbing activity, represents a health problem of aging. The consequence is the negative balance of bone turnover that can lead to osteoporosis. Physical activity (PA) can play a central role in the comprehensive management of…[Read more]

  • Two rounds of literature review using a three-step method will be performed. Risk of Bias assessment will be performed using Covidence, and quality assessment of selected articles will be done using the Critical Appraisal Skills Programme (CASP) checklist.

    The results of the systematic review will consider the reported context in which…[Read more]

  • The results of this study demonstrated a sedentary lifestyle in young adults during the COVID-19 pandemic, which will assist health policymakers and practitioners in the development of population specific health education and behavior interventions during this pandemic and for other future events.Wound healing constitutes an essential process for…[Read more]

  • Due to the rich vitamin content in citrus fruit, citrus is an important crop around the world. However, the yield of these citrus crops is often reduced due to the damage of various pests and diseases. In order to mitigate these problems, several convolutional neural networks were applied to detect them. It is of note that the performance of these…[Read more]

  • Prognosis and survival rates for breast cancer vary greatly depending on the cancer stage of the patient. Instead of a step-by-step approach using multiple investigations, we can get all the information about the metastatic load of the disease in PET-CT imaging by one single investigation. There is also a correlation between prognosis, FDG uptake,…[Read more]

  • It was generally believed that weak van der Waals interactions exist between neighboring layers in the two-dimensional group-IV chalcogenides. Using PbSe as a prototypal example, we find additional strong coupling between the Pb-Pb layers, as evidenced by detailed analysis of the differential charge density plot. The coupling is covalent-like and…[Read more]

  • IP3R debt underlies loss of salivary fluid secretion in Sjögren’s Affliction.

    Eighteen species of rickettsiae are reported to cause infections in humans. One of these is Rickettsia helvetica, which is endemic in European and Asian countries and transmitted by the tick Ixodes ricinus. Besides fever, it has been demonstrated to cause meningitis…[Read more]

  • We report the colloidal synthesis of a series of surfactant-stabilized lead chalcohalide nanocrystals. Our work is mainly focused on Pb4S3Br2, a chalco-halide phase unknown to date that does not belong to the ambient-pressure PbS – PbBr2 phase diagram. The Pb4S3Br2 nanocrystals herein feature a remarkably narrow size distribution (with a size…[Read more]

  • Melanoma is one of the most aggressive types of cancer that has become a world-class problem. According to the World Health Organization estimates, 132,000 cases of the disease and 66,000 deaths from malignant melanoma and other forms of skin cancer are reported annually worldwide ( https//apps.who.int/gho/data/?theme=main ) and those numbers…[Read more]

  • Cancer is a disease that evolves continuously with unpredictable outcomes. Although conventional chemotherapy can display significant antitumor effects, the lack of specificity and poor bioavailability remain major concerns in cancer therapy. Moreover, with the advent of novel anti-cancer gene therapies, there is an urgent need for drug delivery…[Read more]

  • g., generalized linear models or generalized additive models). We thus provide a generalization of Wright’s path rules that accommodates the nonlinear and nonadditive mechanisms by which natural selection commonly arises.During the past decade, ‘alcohol’s harm to others’ (AHTO) has emerged as an international approach to studying alcohol problems…[Read more]

  • not on beta-blockers (HR 0.8, 95% CI 0.58 to 1.11, p = 0.18).In conclusion, beta-blocker therapy did not affect 30 days MACE or 1-year survival after myocardial infarction in patients without heart failure or reduced ejection fraction.Food parenting practices are considered to have a key influence on children’s dietary habits, with potential long…[Read more]

  • Tuberculosis preventive treatment (TPT) is a critical intervention to reduce TB mortality among people living with HIV (PLHIV). To facilitate scale-up of TPT among PLHIV, the Nigeria Ministry of Health and the US Centers for Disease Control and Prevention (CDC) Nigeria, supported by US President’s Emergency Plan for AIDS Relief (PEPFAR)…[Read more]

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