• Background Anterior sacral meningocele (ASM) is a rare congenital anomaly. It is characterized by herniation of the dura through a defect in the anterior sacrum. Rarely, however, it may extend to the rectal area through a rectothecal fistula with or without rectorrhea. Case description Here, we present a case of ASM associated with a rectothecal…[Read more]

  • Then, inspired by the manifold sensing characteristic (MSC), the manifold space is established based on diffusion maps (DM) to reveal the intrinsic evolutionary law of health degradation. Finally, the geodesic distance is employed to represent the deviation between the current state and health baseline. As a health indicator, the confidence value…[Read more]

  • Complete stone clearance was seen in 94.8% of patients using air to only 75% of patients using contrast. Conclusion Air pyelogram is a feasible, safe, cost effective and efficient access alternative to contrast pyelogram and in difficult situation a mixture of both is better than using one.

    There are notable geographic variations in incidence…[Read more]

  • The present analysis explores whether demographic, psychosocial, or intervention adherence factors moderated treatment efficacy of Finding My Way (FMW), an efficacious self-directed web-based psychosocial program for newly diagnosed curatively treated cancer patients.

    Participants (n = 191) completed a 6-module intervention (n …[Read more]

  • Moreover, both the driving forces that facilitate chiral bias and the supramolecular interactions that play an important role in the expression, transfer, and amplification of the chiral sense are correspondingly discussed.It remains a daunting task to quantify the configurational entropy of a material from atom-revolved electron microscopy images…[Read more]

  • Spinal high mobility group box 1 protein (HMGB1) plays crucial roles in arthritis-induced pain; however, the involvement of peripheral HMGB1 has not been examined previously. In this study, we addressed the role of peripheral HMGB1 and explored if sex contributes differentially to nociception in arthritis. We found Hmgb1 expression to be elevated…[Read more]

  • Mullen Ho posted an update 7 months, 4 weeks ago

    zepine treatment but not significantly so (RR 2.53, 99% CI 0.27 to 23.85; fixed-effect model; 6 studies; moderate-certainty evidence). AUTHORS’ CONCLUSIONS Oxcarbazepine might be effective at reducing seizure frequency when used as an add-on for drug-resistant focal epilepsy. The efficacy outcomes – 50% or greater seizure reduction and seizure…[Read more]

  • Our study will clarify the distribution of gut flora in patients with Keshan disease and the abundance and population changes of gut flora in different stages of the disease. Through the big data platform analyze the relationship between environmental factors, clinical factors, and gut flora, the main factors affecting the occurrence of Keshan…[Read more]

  • Hereditary amegakaryocytic thrombocytopenia : Not just a single disease.

    To evaluate the effect of delayed start of combination therapy (CT) with dutasteride 0.5mg and tamsulosin 0.4mg on the risk of acute urinary retention or benign prostatic hyperplasia (BPH)-related surgery (AUR/S) in patients with moderate-to-severe lower urinary tract…[Read more]

  • weight gain, thus improved the growth performance of broiler chickens.Celiac disease (CD) is a gastrointestinal disorder whose genetic basis is not fully understood. Therefore, we studied a Saudi family with two CD affected siblings to discover the causal genetic defect. Through whole exome sequencing (WES), we identified that both siblings have…[Read more]

  • Consanguinity was positive in 18 families of the cohort (69.0%). Seven patients showed homozygous mutations. Five patients had heterozygous mutations. There were six patients with VUS and six patients had negative WES results. Whole exome sequencing showed a high diagnostic rate in this group of children with variable neurological…[Read more]

  • Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide. ESCC has a generally poor prognosis and there is a lack of available biomarkers for diagnosis and prognosis. The aim of the study was to identify novel biomarkers for ESCC. We screened the overlapping differentially expressed genes (DEGs) acquired from six Gene…[Read more]

  • Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administration in early pregnancy on fetal development. We hypothesised that maternal early pregnancy progesterone…[Read more]

  • Raun Gunn posted an update 7 months, 4 weeks ago

    Pulsed micro-arc oxidation (MAO) in a strongly alkaline electrolyte (pH > 13), consisting of Na2SiO3⋅9H2O and NaOH, was used to form a thin porous oxide coating consisting of two layers differing in chemical and phase composition. The unique procedure, combining MAO and removal of the outer layer by blasting, enables to prepare a coating suita…[Read more]

  • In addition, although the endotoxin activity was found to have decreased due to LER phenomenon, the particle size distribution of endotoxin determined by dynamic light scattering (DLS) in LER solution did not change obviously, which is different from previous hypothesis about LER phenomenon in literature that the particle size of endotoxin…[Read more]

  • Emerging therapeutics that are promising for overcoming drug resistance are also discussed.Therapeutic targeting of blood coagulation is a challenging task as it interferes with the delicate balance of pro- and anticoagulant activities. Anticoagulants are employed in millions of thrombophilic patients worldwide each year. The treatment and…[Read more]

  • Although 2D materials have been widely studied for more than a decade, very few studies have been reported on the in-plane structure domain (STD) size even though such a physical property is critical in determining the charge carrier and energy carrier transport. Grazing incidence X-ray diffraction (XRD) can be used for studying the in-plane…[Read more]

  • There is an exponential growth in the numbers of procedures requiring large-bore access. InSeal vascular closure device (VCD) is a novel device that seals the puncture with a biodegradable membrane, which is supported by a self-expanding nitinol frame. The current study suggests that the InSeal VCD is safe and effective in achieving hemostasis…[Read more]

  • 01). Differences were found between groups (alcohol, gambling, alcohol + gambling and neither) on self-rated energy and fatigue as well as pain (ps  less then  .05). Gambling and alcohol problems may relate to emotional and health problems, and personality and belief systems may be related to the co-occurrence of gambling and alcohol problem…[Read more]

  • uation.

    Healthcare professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier and furthermore, there is no consensus on which medications are considered as FRIDs despite several systematic reviews. Filgotinib chemical structure To support clinicians in the…[Read more]

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