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Gould Rafn posted an update 8 months ago
This proof-of-concept-study demonstrated the usability and reproducibility of Nephroscreen for the detection of DIKI and drug-transporter interactions. Nephroscreen it represents a valuable tool towards replacing animal testing and supporting the 3Rs (Reduce, Refine and Replace animal experimentation).
Polysorbates (PS) are used in…[Read more]
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McDonough Borup posted an update 8 months ago
Utilizing a population-based sample of young people (7332 individuals, including 3639 males and 3693 females), a prospective cohort study was undertaken.
We modeled the association between incontinence/LUTS and mental health outcomes using multivariable regression, accounting for potential influences of sex, socioeconomic position,…[Read more]
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MacGregor Herbert posted an update 8 months ago
More than 25% of patients with COVID-19 were asymptomatic.•Among patients with COVID-19, 26.1% presented anosmia, and 22.6% complained of ageusia with median duration of 7 days.•Mean duration of SARS-CoV-2 viral shedding was 24.5 days.•Irrespective of clinical manifestations, all patients with COVID-19 showed prolonged viral shedd…[Read more]
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Overgaard Vega posted an update 8 months ago
Four novel polyoxouranium-based uranyl carboxylates have been constructed by using a combination of three silicon-centered carboxylate ligands and polyoxouranium building blocks. Interesting oligomerization of the uranyl groups from three types of tetrameric units in 1 and 2 to octameric 8+ in 3 and ultimately infinite polyoxouranium chains in 4…[Read more]
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Emerson Slaughter posted an update 8 months ago
Evidence to support this includes the significant differences between samples using PERMANOVA (p less then 0.001), the clear separation in ordination space of samples clustered by sampling method, the significantly higher richness in the surface samples (p less then 0.001), and the considerable variation in relative abundances of various taxa and…[Read more]
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Dawson Koefoed posted an update 8 months ago
Hypophosphatemia appears to be a marker of disease severity. Limited number of available studies and varied study designs did not allow for the ascertainment of the effect of severe hypophosphatemia on patient mortality.
Hypophosphatemia in ICU was associated with increased hospital and ICU length of stay but not all-cause mortality.…[Read more]
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Balling Salazar posted an update 8 months ago
Portela.Emerging and endemic animal viral diseases continue to impose substantial impacts on animal and human health. Most current and past molecular surveillance studies of animal diseases investigated spatio-temporal and evolutionary dynamics of the viruses in a disjointed analytical framework, ignoring many uncertainties and made joint…[Read more]
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Guzman McHugh posted an update 8 months ago
The role of docosahexaenoic acid (DHA) and arachidonic acid (AA) in neurogenesis and brain development throughout the life cycle is fundamental. DHA and AA are long-chain polyunsaturated fatty acids (LCPUFA) vital for many human physiological processes, such as signaling pathways, gene expression, structure and function of membranes, among others.…[Read more]
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Reynolds Haugaard posted an update 8 months ago
Further studies, are needed to investigate effects of healthy lifestyle changes to improve HRQoL in lymphoma survivors. Research in understanding association of lifestyle factors may guide future support for lymphoma cancer survivors.
MVPA was associated with higher HRQoL in lymphoma survivors regardless of BMI. Further studies, are needed to…[Read more]
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Cummings Vedel posted an update 8 months ago
While large magnitudes of the longitudinal crystal field select the z-spin components either in their states ±3/2 or ±1/2, it is surprising that a large transverse crystal field induces the spin component in the z direction to values ±1, which are completely different from any expected natural component. This comes indeed as a result of the ze…[Read more]
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Buckley Greene posted an update 8 months ago
Emerging evidence suggests that post concussive symptoms, including mood changes, may be improved through morning blue-wavelength light therapy (BLT). However, the neurobiological mechanisms underlying these effects remain unknown. We hypothesize that BLT may influence the effective brain connectivity (EC) patterns within the default-mode network…[Read more]
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Clay Rooney posted an update 8 months ago
Pathways relating to radiation-induced viral mimicry, including HMGB1, NF-κB and interferon signaling cascades, were predicted to be uniquely activated by MRT. Local microglia, as well as circulating leukocytes, including T cells, were predicted to be activated by MRT. Our findings affirm that the transcriptomic signature of MRT is distinct from…[Read more]
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Basse Hooper posted an update 8 months ago
The cumulative effects at lag0-21 increased with the intensities and the durations of cold spells. Under the optimal definition, the most significant single-day relative risk (RR) was found on the days of cold spells (lag0) with an RR of 1.042 (95% CI 1.013 to 1.072), and the CRR at lag0-21 was 1.394 (95% CI 1.193 to 1.630). The elderly (aged…[Read more]
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Ibsen Childers posted an update 8 months ago
At the equatorial zone and anterior central zone of lens, AR expression and TUNEL-positive apoptotic LECs were significantly increased in the DM group compared with the control group, however, they were significantly decreased in the DM + NGF group. In conclusion, topical NGF could delay the progression of diabetic cataracts by attenuating polyol…[Read more]
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Kornum Busch posted an update 8 months ago
French Guiana is an overseas territory of France with marked specificities in terms of populations, socioeconomic factors, risk factors, and an access to care. In this context, the objective of the present study was to describe the epidemiology of acute coronary syndromes in French Guiana and to make comparisons with mainland France and…[Read more]
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Porterfield Tierney posted an update 8 months ago
The severe-pain incidence (NRS > 6, or CPOT > 5) was 5.9% (n = 7). Our incidence of overtreatment was 1.7%. The demographic data and ICU complication-rates of patients with adequate and inadequate pain treatment were similar.
Pain assessment tools in critically ill patients should be developed and validated to the language of the tool…[Read more]
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Lindholm Barrera posted an update 8 months ago
Objective To understand the epidemiology and burden of severe coronavirus disease 2019 (covid-19) during the first epidemic wave on the west coast of the United States. Design Prospective cohort study. Setting Kaiser Permanente integrated healthcare delivery systems serving populations in northern California, southern California, and Washington…[Read more]
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Holder Warren posted an update 8 months ago
The most frequent problem was a “lack of information to professionals” (25.06%), “problems as to the frequency and interval of doses” (22.90%), and “medication underdosing” (16.20%). Dose adjustment (31.50%) and clarifications (30.90%) were the most frequent pharmaceutical interventions. In the second round of Delphi, experts rated 77.77% of…[Read more]
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Rouse Pehrson posted an update 8 months ago
24).
MSI prevalence in OGC was 12.4%, associated with antral localization and advanced age. Patients with MSI tumors had a lower cumulative incidence of recurrence after surgery. MSI phenotype was mainly associated with loss of MLH1 protein expression, MLH1 promotor hypermethylation and had no BRAFV600E mutation.
MSI prevalence in OGC…[Read more]
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Houston Sherrill posted an update 8 months ago
BACKGROUND The prevalence of prehypertension in the world reaches 20-25% with a figure that is still high in Indonesia (48.4%). The role of health promotion is substantial in an effort of prevention and treatment of hypertension. AIM This study aims to determine the difference of effect between health promotion using media slides presentation and…[Read more]
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