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Medeiros Vaughn posted an update 8 months ago
Many mitochondrial diseases are caused by mutations in mitochondrial DNA (mtDNA). Patients’ cells contain a mixture of mutant and nonmutant mtDNA (a phenomenon called heteroplasmy). The proportion of mutant mtDNA varies across patients and among tissues within a patient. We simultaneously assayed single-cell heteroplasmy and cell state in…[Read more]
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Lundgaard Carstensen posted an update 8 months ago
n the asthma trial were lower than in atopic dermatitis trials and were similar for dupilumab- and placebo-treated patients. Most events were mild to moderate, most recovered/resolved, and none prompted study withdrawal. These results are similar to those reported in adult trials and support a drug-disease interaction. CLINICALTRIALS.…[Read more]
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Blum Austin posted an update 8 months ago
Downregulated genes (N = 363) were enriched in annotations associated with behavior (FDR less then 2 × 10-4 ), membrane organization (FDR less then 1 × 10-4 ), inorganic cation transmembrane transporter activity (FDR less then 2 × 10-3 ), synapse part (FDR less then 4 × 10-10 ), glutamatergic synapse (FDR less then 1 × 10-6 ), and GABAergic syna…[Read more]
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Birch McKinney posted an update 8 months ago
In this cohort, the average age was 56.5 years, 63.9% were female, and 36.5% of patients developed the primary outcome. The incidence of the primary outcome was higher in those initially treated with either norepinephrine (47.6%) or dopamine (50.6%) than with phenylephrine (24.5%). After adjusting for possible confounders using propensity score…[Read more]
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Hart McCain posted an update 8 months ago
Seven patients reported positive SARS-CoV-2 exposure from a member of their household.
Hospitalized patients on PD with COVID-19 had a relatively mild course, and majority of them were discharged home.
Hospitalized patients on PD with COVID-19 had a relatively mild course, and majority of them were discharged home.
Accurate…[Read more]
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Maher Dissing posted an update 8 months ago
These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs.During mammalian embryogenesis, differential gene expression gradually builds the identity and complexity of each tissue and organ system1. Here we systematically…[Read more]
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Loomis Butt posted an update 8 months ago
To date, treatment of atrophic acne scars remains a therapeutic challenge for dermatologists, yet there is no standard option on the most effective treatment. Microneedling (MN) is a minimally invasive technology that involves repetitive skin puncture using sterile microneedles to disrupt dermal collagen that connects the scar tissue. Recent…[Read more]
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Ramos Olsson posted an update 8 months ago
Poly(N-vinylpyrrolidone-co-butylacrylate-co-N-hydroxymethylacrylamide) has been synthesized by free radical polymerization at 70 °C. Copolymer were characterized by FT-IR, elemental analysis and viscometric methods. Invertase was immobilized onto poly(N-vinyl pyrrolidone-co-butyl acrylate-co-N-hydroxymethyl acrylamide) by entrapment method.…[Read more]
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Olson Post posted an update 8 months ago
mpatibility with HUVECs, but had no effect on L-929 cell viability. Principle Conclusions We report the development and characterization of a new, dual-functional embolization-visualization system for improving fluorescence-imaged endoscopic surgical resection of hypervascular tumors. © The author(s).Rationale Epigenetic mechanisms are…[Read more]
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Henriksen Walton posted an update 8 months ago
We find that the more complicated dependence of DOP on strain, as derived by the analytic model, fits the data better than the previously assumed simple dependence. This finding thus corroborates the analytical model and should have an impact on understanding the strain-dependent operation of optoelectronic devices.
To explore whether…[Read more]
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Freeman Torres posted an update 8 months ago
We suggest that this could be because only higher scores in the GII between men and women show health benefits.
The cost-sharing impact on hospital service utilization of different services is a critical issue that has not been well addressed worldwide. This study aimed to investigate the cost-sharing effects based on income status on hospital…[Read more]
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Bauer Price posted an update 8 months ago
Ocular hypertension occurs due to increased resistance to aqueous humor removal through the conventional outflow pathway. Unlike the proximal region of the conventional outflow pathway, the distal region has not been well studied, mostly due to lack of model systems. Here we describe isolation and characterization of human primary vascular distal…[Read more]
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Carstens Arthur posted an update 8 months ago
Results reveal that nursing diagnoses related to universal self-care requisites can emphasize the impairment or potentialities of the individuals performing self-care. It also shows a lack of consensus on nominating the nursing diagnoses of people with a deficit in universal self-care requisites, resulting in different diagnoses to express the…[Read more]
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Yang Lockhart posted an update 8 months ago
Depressive symptoms in early adulthood were indirectly related to major depressive disorder (MDD) through two independent paths, including the stability of depressive symptoms over time, and through the influence of depression on increasing the tendency to use substances to cope with stress. Our results underscore that coping effects provide…[Read more]
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Polat Bateman posted an update 8 months ago
The formation of the epiphyseal bone plate, the flat bony structure that provides strength and firmness to the growth plate cartilage, was studied in the present study by using light, confocal, and scanning electron microscopy. Results obtained evidenced that this bone tissue is generated by the replacement of the lower portion of the epiphyseal…[Read more]
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Villumsen Ziegler posted an update 8 months ago
Humans have unique cognitive capacities that, compared with apes, are not only simply expressed as a higher level of general intelligence, but also as a quantitative difference in sociocognitive skills. Humans’ closest living relatives, bonobos (Pan paniscus), and chimpanzees (Pan troglodytes), show key between-species differences in social…[Read more]
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Kold Cobb posted an update 8 months ago
Viral relapse is a major concern in hepatitis C virus (HCV) antiviral therapy. Currently, there are no satisfactory methods to predict viral relapse, especially in the era of direct acting antivirals in which the virus often quickly becomes undetectable using PCR-based approaches that focus on a small viral region. Next-generation sequencing (NGS)…[Read more]
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Carson Svane posted an update 8 months ago
Currently, most basketball research is focused on professional and elite players. Studies at the amateur level are important to explain the physical and technical demands of competition and thus improve players’ and teams’ performance. The purpose of the present study was to describe the competitive demands of an amateur-level basketball team and…[Read more]
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Webster Brown posted an update 8 months ago
Aims The aim of this study was to determine the best approach to reduce the unfavorable change in the three different dimensions of impressions using disinfection durations of 15 and 30 min; three different disinfection procedures; and alginate impression products as research factors. Materials and Methods CA37, impressional, and cream alginate…[Read more]
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Steele Hood posted an update 8 months ago
Additionally, Treg cells were decreased in mice with IRAEs. Lastly, the proportion of CD4+/CD8+ T cells dramatically increased after the administration of ipilimumab. And the degree of IRAEs may be related to CD56+ expression in HPDOX.
Our study established HPDOX mice models for investigating the mechanism and IRAEs of immunotherapies in…[Read more]
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