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Hess Godfrey posted an update 8 months ago
Raloxifene hydrochloride (RLX) shows poor bioavailability (90%). The objective of this study was to develop nanostructured lipid carriers (NLCs) for RLX to enhance its bioavailability. The NLC formulations were produced with glyceryl tribehenate and oleic acid. The particle characteristics, entrapment efficiency (EE), differential scanning…[Read more]
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Schroeder Vest posted an update 8 months ago
The world is in the grip of the COVID-19 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. This article reviews the roles of vitamin D in reducing the risk of respiratory tract infections, knowledge about the epidemiology of influenza and COVID-19, and how vitamin D…[Read more]
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Cullen Rasch posted an update 8 months ago
Studies have yielded contradictory results concerning the association between dehydroepiandrosterone sulfate (DHEAS) and mortality in the elderly population. This meta-analysis aimed to evaluate the association of low serum DHEAS level with cardiovascular or all-cause mortality in the elderly population. A comprehensive literature search was…[Read more]
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Timmons Valentin posted an update 8 months ago
If this hypothesis is correct, targeting gene therapy to the retinal periphery even in advanced cases may be feasible and could potentially be used to preserve navigational vision.
Although retinal gene therapy is commonly targeted to the macular area in choroideremia, the observation of a rhegmatogenous retinal detachment indicates that the…[Read more]
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Hjelm McQueen posted an update 8 months ago
The interpretability and practical significance of our model are explained in detail in this study.
The study on the dynamical changes of Italian region networks reveals the dynamic of COVID-19 transmission at the network level. It is noteworthy that the driving force of MST-DNM only relies on small samples rather than years of time series…[Read more]
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Richmond Daly posted an update 8 months ago
Technical success was achieved in all cases. Perioperative mortality was observed in 1 (3%) patient and perioperative complications in 2 (6%). During the follow-up were reported 2 symptoms recurrence; a significant ABI increase (0.57; IQR0.41-0.47 vs. 0.69; IQR0.50-0.67; P < 0.01); 1 (3%) major and 2 (6%) minor amputations. selleck Estimated 24…[Read more]
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Foster Kaplan posted an update 8 months ago
The introduction of thrombolytic therapy in the 1990s has transformed acute ischemic stroke treatment. Thus far, intravenous recombinant tissue plasminogen activator (rt-PA) also known as alteplase is the only thrombolytic proven to be efficacious and approved by the United States Food and Drug Administration. But the thrombolytic agent…[Read more]
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Villumsen Meyers posted an update 8 months ago
A nomogram incorporating these independent predictors with a good discrimination (0.79 in C-index) and calibration was constructed to predict the incidence of MACE within 1 year. It could be used to help select the patients with a high risk of MACE and develop preventive treatment strategies.
Risk factors of CAD, PTFV1, CRP, and E/Em were…[Read more]
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Joseph Dixon posted an update 8 months ago
Therefore, we demonstrated that the electrode potential could effectively and reversibly modulate both EME and chemical enhancement in Au@Ag NPoNE structures.We report a simple and rapid microfluidic approach to produce core-shell hydrogel microspheres in a single step. We exploit triple emulsion drops with sacrificial oil layers that separate two…[Read more]
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Barrera Blake posted an update 8 months ago
The heritability of GPD was estimated as 0.44, based on data from the field trials of 30 and 40 genotypes. The largest component contributing to the genetic variance was genotype (0.30), with a smaller contribution of the interaction between genotype and year/site (0.11) and a small (but statistically significant) contribution of nitrogen level.…[Read more]
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Shaffer Bjerring posted an update 8 months ago
Our study reports the characteristics of patients with this syndrome in our population.
The invasive liver abscess syndrome due to Klebsiella pneumoniae is a rare life-threatening disease. Our study reports the characteristics of patients with this syndrome in our population.
The prevalence of neuropsychiatric disorders in HIV infected…[Read more]
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Cochran Hatch posted an update 8 months ago
Transposon calling cards is a genomic assay for identifying transcription factor binding sites in both bulk and single cell experiments. Here we describe the qBED format, an open, text-based standard for encoding and analyzing calling card data. In parallel, we introduce the qBED track on the WashU Epigenome Browser, a novel visualization that…[Read more]
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Ibsen Gadegaard posted an update 8 months ago
The ongoing global pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is marked as one of the most challenging infectious diseases in the history of mankind with affliction of ~29,737,453 confirmed cases globally. Looking at the present scenario where there is a parallel increment in curve with time, there is an utmost…[Read more]
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Fox Hammer posted an update 8 months ago
The study of the human microbiome in oncology is a growing and rapidly evolving field. In the past few years, there has been an exponential increase in the number of studies investigating associations of microbiome and cancer, from oncogenesis and cancer progression to resistance or sensitivity to specific anticancer therapies. The gut microbiome…[Read more]
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Lee Hood posted an update 8 months ago
e. until the personal erythemal threshold is reached. Then, sunscreens should be applied.Although Ultraviolet-B (UV-B)-plant interactions have been extensively analysed in the past years, many physiological aspects of the complex plant response mechanisms still need to be elucidated. Depending on the energy dose, this part of the electromagnetic…[Read more]
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Merritt Macias posted an update 8 months ago
Huntington’s disease (HD) is a neurodegenerative disorder caused by a trinucleotide repeat expansion in the huntingtin gene. Transcriptomic dysregulations are well-documented in HD and alterations in small non-coding RNAs (sncRNAs), particularly microRNAs (miRNAs), could underpin that phenomenon. Additionally, environmental enrichment (EE), which…[Read more]
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Copeland Pugh posted an update 8 months ago
y.
Level III, retrospective comparative study.Tambaqui Colossoma macropomum is the most produced native fish in South America. Besides the lack of knowledge regarding bacteria-stricken diseases, the unappropriated using of off-label therapies are common. In this study, Aeromonas hydrophila pathogenicity for tambaqui was first established by…[Read more]
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Keegan Horton posted an update 8 months ago
Copyright © 2020 Clinical and Experimental Hepatology.Aim of the study The quantitative hepatitis B surface antigen (qHBsAg) level indicates the amount of transcriptional activity of covalently closed circular DNA (cccDNA) and integrated DNA in hepatocytes which plays a role in development of chronic hepatitis B (CHB) and may help decide whether…[Read more]
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Sampson Horton posted an update 8 months ago
The mechanism of how environmental regulations (ERs) affect export sophistication (ES) is complex, and for many years, it has been a hot topic for researchers. However, few previous studies have focused on whether ERs can promote the upgrading of China’s ES through foreign direct investment (FDI). To address this research gap, in this study, ERs,…[Read more]
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Dogan Simon posted an update 8 months ago
Trunk control during gait in children with cerebral palsy (CP) is known to be impaired. While differentiation of trunk movement between CP subtypes (unilateral/bilateral) has been examined, differentiation of lower lumbar spinal loading has not been considered. Furthermore, the relationship between lower lumbar loading and lower limb pathology has…[Read more]
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