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Leon Sinclair posted an update 9 months, 3 weeks ago
Usnic acid has anti-cancer activity, however, low solubility and toxicity limit the potential. To investigate biological activity of usnic acid derivatives, enantiopure derivatives were synthesised by reacting usnic acid with ethylenediamine, which yielded one dimer product ((+)-1), and two tetra cyclic compounds ((+)-2 and (-)-2). The products…[Read more]
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Skov Fuller posted an update 9 months, 3 weeks ago
Subcortical structural shape showed less correlation with FLUTE global retention in both EOAD and LOAD. Multiple cognitive domains, except memory function, correlated with the bilateral amygdala, caudate, and putamen in EOAD patients, while more restricted regions in the subcortical structures were correlated with neuropsychological test results…[Read more]
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Odom Ulriksen posted an update 9 months, 3 weeks ago
Management of pituitary conditions can be problematic with many patients experiencing long-term psychological and social difficulties that impact on their quality of life. This study aimed to identify psychosocial symptoms associated with pituitary conditions that lead to poor quality of life and identify differences in symptomatology between…[Read more]
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Covington Hartvig posted an update 9 months, 3 weeks ago
Specifically, results lend support to the hypothesis that the time-varying interplay between large-scale functional brain systems associated with cognitive control is implicated in smoking lapse behavior.
Corneal abrasions are common ophthalmic presentations to emergency departments. Among emergency physicians and ophthalmologists, there are…[Read more]
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Hampton McElroy posted an update 9 months, 3 weeks ago
STUDY QUESTION Are there any differences in the pubertal development and reproductive hormone status during adolescence between singletons following ICSI therapy or spontaneous conception (SC)? SUMMARY ANSWER Pubertal development and reproductive hormone levels are largely similar between ICSI and SC adolescents, except for a tendency towards…[Read more]
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Hedrick Watkins posted an update 9 months, 3 weeks ago
In item response theory, uncertainty associated with estimated item parameters can lead to greater uncertainty in subsequent analyses, such as estimating trait scores for individual examinees. Most existing methods to characterize or correct for item parameter uncertainty implicitly assume that the latent trait continuum is fixed across the…[Read more]
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Schwartz McMahan posted an update 9 months, 3 weeks ago
Artemisia argyi is widely used as traditional medicine in East Asia. However, its effects against inflammation and gastric ulcers have not been reported yet. We analyzed anti-inflammatory activity and its molecular mechanisms of A. argyi using RAW264.7 cells line, then evaluated the curative efficacy in rats with acute gastric ulcers. Nitric oxide…[Read more]
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Marcher Houghton posted an update 9 months, 3 weeks ago
This article presents the case of an accidental transdermal opioid intoxication in a paramedic. During an ambulance flight mission for patient repatriation several ampules containing opioids were broken unnoticed inside the ampule kit in the outside pocket of the work trousers of the paramedic. He developed the typical clinical picture of opioid…[Read more]
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Pallesen Mann posted an update 9 months, 3 weeks ago
Prediction of the dynamics of new SARS-CoV-2 infections during the current COVID-19 pandemic is critical for public health planning of efficient health care allocation and monitoring the effects of policy interventions. We describe a new approach that forecasts the number of incident cases in the near future given past occurrences using only a…[Read more]
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Morton Secher posted an update 9 months, 3 weeks ago
INTRODUCTION A comprehensive characterisation of the tumour microenvironment is lacking in neuroendocrine tumours (NETs), where programmed cell death-1 receptor-ligand (PD-1/PD-L1) inhibitors are undergoing efficacy testing. OBJECTIVE We investigated drivers of cancer-related immunosuppression across NETs of various sites and grade using…[Read more]
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Bach Thorpe posted an update 9 months, 3 weeks ago
Two studies conducted during the 2016 presidential campaign examined the dynamics of the objectivity illusion, the belief that the views of “my side” are objective while the views of the opposing side are the product of bias. In the first, a three-stage longitudinal study spanning the presidential debates, supporters of the two candidates…[Read more]
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Aguirre Mcmillan posted an update 9 months, 3 weeks ago
91% had an incident, low-impact fracture. Mean T-score BMD was - 1.09 ± 1.53 for the spine, - 1.08 ± 1.02 for the femoral neck, and - 0.72 ± 0.96 for the total hip. Mean spine TBS was 1.320 ± 0.10. We found a positive association between hs-CRP and BMD at all sites, and between hs-CRP and the TBS, but none of these associations were significa…[Read more]
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Zimmerman Eskesen posted an update 9 months, 3 weeks ago
Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of cellular sorting processes and can drive severe physiological outcomes. Sorting nexin 27 (SNX27) is a metazoan-specific sorting nexin protein from the PX-FERM domain family and is required for endosomal recycling of many important transmembrane receptors.…[Read more]
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Sweeney Abildtrup posted an update 9 months, 3 weeks ago
Psychological morbidity in inflammatory bowel disease is common with significant impact on quality of life and health outcomes, but factors which predict the development of psychological morbidity are unclear.
To undertake a systematic literature review of the predictors of psychological morbidity in patients with inflammatory bowel…[Read more]
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Skov Dillard posted an update 9 months, 3 weeks ago
Univariable analysis revealed intraepithelial CD8+ cell density as the strongest predictor of endometrial cancer recurrence; multivariable analysis confirmed this was independent of pathologic factors and molecular subgroup. Exploratory analysis suggested this association was not uniform across molecular subgroups, but greatest in tumors with…[Read more]
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Pallesen Kang posted an update 9 months, 3 weeks ago
Breast cancer is the second leading cause of death in women above 60 years in the US. Screening mammography is recommended for women above 50 years; however, 22% of breast cancer cases are diagnosed in women below this age. We set out to develop a test based on the detection of cell-free RNA from saliva. To this end, we sequenced RNA from a pool…[Read more]
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Wynn McKenna posted an update 9 months, 3 weeks ago
Our results provide new insights into the patterns of brain evolution among animals that live under extreme conditions.The evolutionary history of organisms with poor dispersal abilities usually parallels geological events. Collisions of the Indian and Arabian plates with Eurasia greatly changed Asian topography and affected regional and global…[Read more]
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McMillan Dickens posted an update 9 months, 3 weeks ago
The Thai medical application for patient triage, namely Triagist, is an mHealth application designed to support the pre-hospital process. However, since the functions of the application that are necessary for the pre-hospital process have been found not to be fully developed, the addition of a back-end system has been considered to increase its…[Read more]
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Irwin Bonde posted an update 9 months, 3 weeks ago
The genuine Chinese medicinal (GCM), also known as Dao-di Herbs, is a synonym for high quality Chinese medicinal materials, which has been established in thousands of years of clinical practice and is a comprehensive standard for evaluating the quality of Chinese medicinal materials. The newest data from the Fourth National Survey of Chinese…[Read more]
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Compton Carlsson posted an update 9 months, 3 weeks ago
Protein phosphatases, by counteracting protein kinases, regulate the reversible phosphorylation of many substrates involved in synaptic plasticity, a cellular model for learning and memory. A prominent phosphatase regulating synaptic plasticity and neurologic disorders is the serine/threonine protein phosphatase 1 (PP1). PP1 has three isoforms…[Read more]
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