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Stephens Miranda posted an update 8 months, 1 week ago
This review aims to present literature data on the action of the CCL2-CCR2 axis in the central nervous system under physiological and pathological conditions, as well as the contribution of this ligand-receptor system to the processes underlying affective disorders. Additionally, this article draws attention to the importance of the CCL2-CRR2…[Read more]
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Filtenborg Vinther posted an update 8 months, 1 week ago
These metabolites are mainly involved in six amino acid metabolic pathways. In addition, 3-hydroxyphenylacetic acid and N-acetyl-d-phenylalanine showed the highest AUC values of 0.934 and 0.929 in receiver operating characteristic analysis. Through LCMS metabolomics, our study identified potential biomarkers in PE, differentiating EGFR-TKI…[Read more]
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Hatcher Hall posted an update 8 months, 1 week ago
Given the distinctive nature of peptide morphogens and small RNAs, how might mechanisms underlying the function of traditionally morphogens be adapted to create morphogen-like behavior using small RNAs? In this review, we highlight the contributions of mobile small RNAs to pattern formation in plants and summarize recent studies that have advanced…[Read more]
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Carlsson Neergaard posted an update 8 months, 1 week ago
An immune checkpoint PD-1 inhibitor, nivolumab, was approved as second-line therapy for patients who had failed initial chemotherapy, based on the results of the MERIT study. Various clinical immunotherapy trials are ongoing in patients with advanced MPM. In this review, we describe recent knowledge on epigenetic alterations, which might identify…[Read more]
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McClure Knudsen posted an update 8 months, 1 week ago
The urgency for a protein transition towards more sustainable solutions is one of the major societal challenges. Microbial protein is one of the alternative routes, in which land- and fossil-free production should be targeted. The photohydrogenotrophic growth of purple bacteria, which builds on the H2- and CO2-economy, is unexplored for its…[Read more]
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Cleveland Barlow posted an update 8 months, 1 week ago
05). Complement 8 beta chain (C8B) expression levels had protective effects on overall survival (OS) and recurrence-free survival (RFS) in HBV-related HCC patients. High levels of C8B contributed to favorable OS and RFS in this population (both p < 0.01), even after adjustment of clinicopathological characteristics including tumor node metastasis…[Read more]
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Elgaard Baird posted an update 8 months, 1 week ago
Currently, blade-coated perovskite solar cells (PSCs) with high power conversion efficiencies (PCEs), that is, greater than 20%, normally employ methylammonium lead tri-iodide with a sub-optimal bandgap. Alloyed perovskites with formamidinium (FA) cation have narrower bandgap and thus enhance device photocurrent. However, FA-alloyed perovskites…[Read more]
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Bank Fischer posted an update 8 months, 1 week ago
the methods which were used for antibiotic susceptibility testing in our center might cause uncertainty about the results and internationally agreed minimal inhibitory concentration breakpoints and disk-diffusion test thresholds for susceptibility testing for Burkholderia is still a gap to fill for the current literature.BACKGROUND Escherichia…[Read more]
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Ochoa Hassing posted an update 8 months, 1 week ago
We use 3 case studies based on data from soil-transmitted helminth impact surveys in Kenya, Sierra Leone, and Zimbabwe to compare the predictive performance of model-based geostatistics with methods described in current World Health Organization (WHO) guidelines. In all 3 cases, we find that model-based geostatistics substantially outperforms the…[Read more]
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Mathiassen Kragh posted an update 8 months, 1 week ago
Risk assessments of transfusion-transmitted emerging infectious diseases (EIDs) are complicated by the fact that blood donors’ demographics and behaviors can be different from the general population. Therefore, when assessing potential blood donor exposure to EIDs, the use of general population characteristics, such as U.S. travel statistics, may…[Read more]
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Leblanc Sloth posted an update 8 months, 1 week ago
4% yr-1 in IGP, and -1.0% yr-1 in the rest of India. Ammonia is positively correlated with total fertilizer consumption (r = 0.75) and temperature (r = 0.5) since high temperature favors volatilization, and is anti-correlated with total precipitation (r = from -0.2, but -0.8 in the Rabi season October-February) as wet deposition helps removal of…[Read more]
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Wilder Rasch posted an update 8 months, 1 week ago
Unfolding and refolding of multidomain proteins under force have yet to be recognized as a major mechanism of function for proteins in vivo. In this review, we discuss the inherent properties of multidomain proteins under a force vector from a structural and functional perspective. We then characterize three main systems where multidomain proteins…[Read more]
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Thomassen Ebbesen posted an update 8 months, 1 week ago
Motivated by recent nonlocal transport studies of quantum-Hall-magnet (QHM) states formed in monolayer graphene’s N=0 Landau level, we study the scattering of QHM magnons by gate-controlled junctions between states with different integer filling factors ν. For the ν=1|-1|1 geometry we find that magnons are weakly scattered by electric potential v…[Read more]
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Karlsson Lindsay posted an update 8 months, 1 week ago
Several strategies, including chemotherapy and radiotherapy, have improved therapeutic outcomes among cancer patients in clinical practice. However, due to their heterogeneity, cancer cells frequently display primary or acquired therapeutic resistance, thereby resulting in treatment failure. The mechanisms underlying cancer therapeutic resistance…[Read more]
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Barrett Bruun posted an update 8 months, 1 week ago
Thus, we observed a phenotypic plasticity between both subspecies, which did not correspond with a real genotypic variability nor different environmental or ecological conditions. Basing on these results, we could consider that there are no solid arguments to consider these two ‘morphosubspecies’ as two different taxa. We propose that C. b.…[Read more]
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Kirkpatrick Bell posted an update 8 months, 1 week ago
The diagnosis of traumatic transection of main bronchus is often delayed, resulting in attempts at surgical repair sometimes even months after the injury. Our aim is to analyze the factors affecting surgical outcome in patients undergoing lung preserving bronchial re-implantation for bronchial transection.
This is a retrospective analysis…[Read more]
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Moses Winkel posted an update 8 months, 1 week ago
Neuraminidase (NA) is an important target for current research on anti-influenza drugs. The acylhydrazone derivatives containing the -CONHN=CH- framework have been shown to have good NA inhibitory activity. In this paper, a series of novel acylhydrazone NA inhibitors (9a-9n) were designed and synthesized, and the inhibitory activities against NA…[Read more]
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Morales Hougaard posted an update 8 months, 1 week ago
We then distinguish the approaches used, highlight their strengths and drawbacks, and provide a comparison of these approaches. Finally, we identify some research gaps and future directions.Estrogen is an important hormone to regulate skeletal physiology via estrogen receptors. The traditional estrogen receptors are ascribed to two nuclear…[Read more]
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Hamann Neergaard posted an update 8 months, 1 week ago
These findings provide a new mechanism for the renoprotective effects of metformin.3-Hydroxy-3-methyl-glutaryl-co-enzyme-A (HMG-CoA) reductase inhibitors (statins) are popularly used for the treatment of obesity and hypercholesterolemia with established safety profile. Statins exhibits a wide range of neurobehavioral effects in addition to their…[Read more]
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Eriksen Buchanan posted an update 8 months, 1 week ago
The technological advances in mass spectrometry allow us to collect more comprehensive data with higher quality and increasing speed. With the rapidly increasing amount of data generated, the need for streamlining analyses becomes more apparent. Proteomics data is known to be often affected by systemic bias from unknown sources, and failing to…[Read more]
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