• 001% by using purified plasmid DNAs and blood cell DNAs containing known proportions of FLT3D835Y. We analyzed blood cell DNA samples from 64 patients with AML and found six FLT3D835Y-positive cases, two of which could not be detected by conventional DNA sequencing methods. Importantly, the method was able to detect FLT3D835Y in a sample collected…[Read more]

  • Several strategies, including chemotherapy and radiotherapy, have improved therapeutic outcomes among cancer patients in clinical practice. However, due to their heterogeneity, cancer cells frequently display primary or acquired therapeutic resistance, thereby resulting in treatment failure. The mechanisms underlying cancer therapeutic resistance…[Read more]

  • 001).

    Adolescents with PCOS had lower self-concept scores, greater anxiety levels, and increased depressive symptoms than the healthy controls. Future studies are needed to examine the psychiatric problems in adolescents with PCOS.

    Adolescents with PCOS had lower self-concept scores, greater anxiety levels, and increased depressive…[Read more]

  • Motivated by recent nonlocal transport studies of quantum-Hall-magnet (QHM) states formed in monolayer graphene’s N=0 Landau level, we study the scattering of QHM magnons by gate-controlled junctions between states with different integer filling factors ν. For the ν=1|-1|1 geometry we find that magnons are weakly scattered by electric potential v…[Read more]

  • Diabetes mellitus (DM) patients show a significant derangement in various hematological parameters including changes affecting the red blood cells (RBCs). All these derangements have an imposing effect on any of the RBC indices. Thus, the main aim of this study was determining the RBCs parameters and their correlation with renal function, and also…[Read more]

  • This case highlights the importance of searching for underlying cause in a young female presenting with intracranial haemorrhage for the first time and keeping Moyamoya disease as a differential.

    Chronic rhinosinusitis with polyposis (CRSwNP) is a multifactorial naso-sinusal inflammatory disease that affects 2-4% of the adult population. It…[Read more]

  • Upon internalization, receptors are trafficked to sorting endosomes (SE) where they undergo sorting and are then packaged into budding vesicles that undergo fission and transport within the cell. Eps15 Homology Domain Protein 1 (EHD1), the best-characterized member of the Eps15 Homology Domain Protein (EHD) family, has been implicated in…[Read more]

  • Our aim was to evaluate the safety and efficacy of low-dose mineralocorticoid receptor antagonists (MRAs) in dialysis patients.

    We systematically searched PubMed, EMBASE, and Cochrane libraries for clinical trials on the use of MRAs in dialysis patients. Review Manager 5.3 software was used to analyze relevant data and evaluate the quality…[Read more]

  • NPD1 stimulates the synthesis of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and of semaphorin 7A (Sema7A). RvD6i treatment of injured corneas modulates gene expression in the TG resulting in enhanced neurogenesis; decreased neuropathic pain and increased sensitivity. Taken together, these results represent a promising…[Read more]

  • A 64-year-old female presented to our hospital with a chronic cough. She was diagnosed with cStage ⅢA small cell lung cancer(cT2aN2M0, limited disease). On admission for chemoradiation therapy, laboratory data incidentally revealed liver dysfunction. Further examination resulted in the patient being diagnosed with autoimmune hepatitis. Oral p…[Read more]

  • Interstitial lung disease is a well-recognised manifestation and a major cause of morbidity and mortality in patients with connective tissue diseases. Interstitial lung disease may arise in the context of an established connective tissue disease or be the initial manifestation of an otherwise occult autoimmune disorder. Early detection and…[Read more]

  • the methods which were used for antibiotic susceptibility testing in our center might cause uncertainty about the results and internationally agreed minimal inhibitory concentration breakpoints and disk-diffusion test thresholds for susceptibility testing for Burkholderia is still a gap to fill for the current literature.BACKGROUND Escherichia…[Read more]

  • Howe Aaen posted an update 8 months, 1 week ago

    The highest relative abundance and diversity of biting midges were found in May and June. The number of trapped biting midges correlated positively with the mean air temperature. The first biting midges in spring were caught when the mean daily temperature rose higher than 10 °C. No Culicoides were detected when the air temperature dropped below…[Read more]

  • Korthalsia laciniosa (Griff.) Mart. is a climbing rattan used as a source of durable and flexible cane. In the present study, the draft genome of K. laciniosa was sequenced, de novo assembled and annotated. Genome-wide identification of MADS-Box transcription factors revealed loss of Mβ, and Mγ genes belonging to Type I subclass in the rattan l…[Read more]

  • This article is protected by copyright. All rights reserved.A 46-year-old man with no relevant medical history presented to the Emergency Department with a headache, retro-orbital pain, progressive proptosis and periorbital xanthelasmas. He denied bone pain nor any symptoms of diabetes insipidus. An ESR was 40 mm/hour and a CRP was 2.8 mg/dL. A…[Read more]

  • Objectives  The main purpose of this study is to investigate the prevalence of comorbid conditions in diabetic, prediabetic, and nondiabetic individuals. Additionally, the current study examines the levels of awareness of those comorbidities among North Indian population. Methods  As a part of a national study (Niyantrit Madhumeh Bharat scr…[Read more]

  • The phase 3 trial PALISADE, comparing peanut (Arachis hypogaea) allergen powder-dnfp (PTAH) oral immunotherapy versus placebo in peanut-allergic children, reported that a significantly higher percentage of PTAH-treated participants tolerated higher doses of peanut protein after 1year of treatment. This study used PALISADE data to estimate the…[Read more]

  • , Streptococcus pneumoniae, and Mycoplasma pneumoniae By identifying the player contributing to Ap4A homeostasis in these bacteria, we disclose a novel target to develop innovative antibacterial strategies. Copyright © 2020 American Society for Microbiology.BACKGROUND Asian Americans are at higher risk for non-cardia gastric cancers (NCGCs)…[Read more]

  • lation may be a promising therapeutic strategy for DOR.Approximately one in eight visits to the Emergency Department (ED) in the United States are due to a behavioral health crisis. A Midwest community created an Integrated Crisis Team (ICT) as part of its county-wide effort to improve quality of care for people with mental health and/or substance…[Read more]

  • Yu Lyng posted an update 8 months, 1 week ago

    Experiments have been carried out varying the percentage of failed sensors. Results show a good level of prediction accuracy which, as expected, decreases as the failure rate increases. Results also point out a failure rate threshold below which is better to make use of memory-based approaches, and above which is better to choose model-based…[Read more]

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