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Wilder Conley posted an update 7 months, 3 weeks ago
evelopment of type 2 diabetes mellitus.
Our study provides further insight into the factors crucial for behaviour change in women diagnosed with GD. By innovatively applying the COM-B framework in a socioecological context, it is clear intervention facets need to target microlevel through the macrolevel to engage this population in behaviour…[Read more]
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Bullard Lundqvist posted an update 7 months, 3 weeks ago
Clonorchis sinensis is a food-borne trematode that infects more than 15 million people. The liver fluke causes clonorchiasis and chronical cholangitis, and promotes cholangiocarcinoma. The underlying molecular pathogenesis occurring in the bile duct by the infection is little known. In this study, transcriptome profile in the bile ducts infected…[Read more]
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Penn Bredahl posted an update 7 months, 3 weeks ago
In the highly consanguineous and homogeneous population of Saudi Arabia, SRD5A2 and CYP11B1 deficiencies are common causes of DSDs. Other DSDs occur less frequently but often with novel mutations.
In the highly consanguineous and homogeneous population of Saudi Arabia, SRD5A2 and CYP11B1 deficiencies are common causes of DSDs. Other DSDs occur…[Read more]
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Reddy Espersen posted an update 7 months, 3 weeks ago
Here, we conduct a comprehensive review and discussion of the bibliography available regarding the role of polyP in the mitochondrial dysfunction present in AD and PD. Taking into account the data presented in this review, we postulate that polyP could be a valid, innovative and, plausible pharmacological target against mitochondrial dysfunction…[Read more]
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Jain Winkel posted an update 7 months, 3 weeks ago
The mesoporous structure, surface charge and high specific surface area (233.71 m2 g-1, Dmean = 5.65 nm) promote its rapid equilibrium of anionic adsorption within 10 min. In addition, Cu(mDF) possessing an adsorption-induced color-shifting feature provides an ideal platform for organic pollutant detection. Furthermore, Cu(mDF) with…[Read more]
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Pollock Paaske posted an update 7 months, 3 weeks ago
Degenerative disc disease (DDD) in lumbar spine is one of the major musculoskeletal disorders that cause low back pain (LBP). The intervertebral disc structure and dynamics of the lumbar spine are significantly affected by lumbar DDD, leading to a reduced range of motion (ROM), muscle weakness and gradual degradation. Spinal fusion and…[Read more]
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Patterson Levesque posted an update 7 months, 3 weeks ago
In order to study the effects of chlorine dioxide (ClO2) disinfection on the super antibiotic resistance genes (SARGs), the final effluents before and after chlorine dioxide were sampled throughout one year in a wastewater treatment plant (WWTP). The bacteria and extracellular nucleic acid were collected using microporous membrane filtration and…[Read more]
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Richmond Velazquez posted an update 7 months, 3 weeks ago
Rab GTPase is a paralog-rich gene family that controls the maintenance of the eukaryotic cell compartmentalization system. Diverse eukaryotes have varying numbers of Rab paralogs. Currently, little is known about the evolutionary pattern of Rab GTPase in most major eukaryotic ‘supergroups’. Here, we present a comprehensive phylogenetic…[Read more]
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Donaldson Wilkins posted an update 7 months, 3 weeks ago
DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is highly expressed in glioma, an aggressive brain tumor, and has been proposed as a therapeutic target for cancer. In the current study, we have used an optimized and validated time-resolved fluorescence energy transfer (TR-FRET)-based DYRK1A assay for high-throughput…[Read more]
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Sommer Ellis posted an update 7 months, 3 weeks ago
g diverse pain conditions. C75 However, given the variety of study designs and reported treatment outcomes, conclusions about the evidence for eye acupuncture for specific conditions are not possible at this stage.
This randomized clinical trial aimed to compare the preparation time and severity of postoperative pain between HyFlex Electric…[Read more]
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Banks Birch posted an update 7 months, 3 weeks ago
Tuberculosis (TB) is the most prevalent infectious disease in the world. In recent years there has been a significant increase in the incidence of TB due to the emergence of multidrug resistant strains of Mycobacterium tuberculosis (M. tuberculosis) and the increased numbers of highly susceptible immuno-compromised individuals. Central nervous…[Read more]
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Whitehead Gibbons posted an update 7 months, 3 weeks ago
The ability to detect low concentrations of biomarkers in patient samples is one of the cornerstones of modern healthcare. In general, biosensing approaches are based on measuring signals resulting from the interaction of a large ensemble of molecules with the sensor. Here, we report a biosensor platform using DNA origami featuring a central…[Read more]
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Bunn Acosta posted an update 7 months, 3 weeks ago
Glioblastoma multiforme (GBM) is the most malignant brain tumor. Hypoxic condition is a predominant feature of the GBM contributing to tumor growth and resistance to conventional therapies. Hence, the identification of drugs able to impair GBM malignancy and aggressiveness is considered of great clinical relevance. Previously, we demonstrated that…[Read more]
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Kragh Zhou posted an update 7 months, 3 weeks ago
Dermatomyositis (DM) is an autoimmune disease that affects the skin, lungs, and muscle. Although the pathogenesis of DM is not completely understood, several environmental triggers have been linked to DM onset or flare. This article specifically examines the effects of herbal supplements, drugs, infections, ultraviolet (UV) radiation, and…[Read more]
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Sonne Bengtsen posted an update 7 months, 3 weeks ago
The specific interactions among NOR-related genome structures remain unclear and require further investigation. Here, I propose that there are limited and non-limited genomic dispersion systems that result from genomic affinity rules, inducing specific chromosomal configurations that are related to NORs.The objective of this systematic review was…[Read more]
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Ebsen Somerville posted an update 7 months, 3 weeks ago
She required a 2-stage revision procedure with massive allograft. At 1 year after these procedures, the patient is able to walk without a walking aid and does not report groin pain or present signs of dislocation, and radiographs show no loosening of the implant. CONCLUSIONS This case highlights that medial wall post-THA PIF can occur along with…[Read more]
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Albright Gundersen posted an update 7 months, 3 weeks ago
Intense pulsed light (IPL) is becoming a new technical platform for disinfecting food against pathogenic bacteria. Metabolic changes are deemed to occur in bacteria as either the causes or the consequences of IPL-elicited bactericidal and bacteriostatic effects. However, little is known about the influences of IPL on bacterial metabolome. In this…[Read more]
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Sampson Conrad posted an update 7 months, 3 weeks ago
10, p=1.96*10-20). The motif “QAD” of α44, β57, and β135 captured the T1D risk association of DQ8.1 (OR 3.44, p=3.80*10-84), the corresponding motif “CAD” captured the risk association of DQ2.5 (OR 2.10, p=1.96*10-20). Two risk associations were related to GADA and IA-2A, but in opposite directions. “CAD” was positively associated with GADA (OR 1.…[Read more]
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Koch Pape posted an update 7 months, 3 weeks ago
Industrial biotechnology (IB) uses biological and biochemical processes in industrial production and is often regarded as an emerging key technology revolutionizing the production of many products while protecting resources and the environment and fostering economic development. This contribution describes the background and sketches the content…[Read more]
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Mathews Enemark posted an update 7 months, 3 weeks ago
Gepotidacin (GSK2140944) is a first in class, novel triazaacenaphthylene bacterial type II topoisomerase inhibitor in Phase 3 clinical development for the treatment of gonorrhea and uncomplicated urinary tract infections (acute cystitis). This study tested the equivalency of minimal inhibitory concentrations (MICs) obtained by two reference…[Read more]
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