• OBJECTIVE To systematically review and appraise published data, to determine the prevalence of Mycoplasma genitalium (MG) in men who have sex with men (MSM) tested at each anatomical site, that is, at the urethra, rectum and/or pharynx. DESIGN Systematic review and meta-analysis. DATA SOURCES Ovid Medline, PubMed, Embase were searched for articles…[Read more]

  • While religiosity is usually associated with lower death anxiety, holding doubts about one’s faith are associated with higher death anxiety. Using longitudinal data from the Religion, Aging, and Health Study (2001-2004), this study examines within-individual changes in religious doubt and death anxiety. Results from lagged dependent variable…[Read more]

  • Treatment with the clinical ATR kinase inhibitor VX-970 induced apoptosis in MYB-positive ACC cells and growth inhibition in ACC PDXs. To our knowledge, ATR is the first example of an actionable target downstream of MYB that could be further exploited for therapeutic opportunities in ACC patients. Our findings may also have implications for other…[Read more]

  • Precursor B-cell lymphoblastic lymphoma (PBLL) is a rare subtype of non-Hodgkin lymphoma originating from B-cell precursors. PBLL, as a solitary mass lesion affecting the central nervous system without leukemic disease at presentation, is quite uncommon. Here we report a rare PBLL case with Philadelphia chromosome positivity. The 44-year-old male…[Read more]

  • Female patients who had been sexually assaulted and who were evaluated at 13 widely geographically distributed sexual assault nurse examiners’ programs consistently reported that the sexual assault nurse examiners provided high-quality, compassionate care.

    We aimed to assess the long-term outcomes of children in whom the aortic valve could be…[Read more]

  • Pyroptosis is a type of proinflammatory regulated cell death (RCD) in which caspase-1 proteolytically cleaves gasdermin D (GSDMD) to yield a cytotoxic pore-forming protein. Recent studies have suggested that additional cell death pathways may interact with GSDMD under certain circumstances to execute pyroptosis. Microglia/macrophages in the…[Read more]

  • To investigate the evidence and provide clinical recommendations for low intensity exercises(LIE) and blood flow restriction(BFR) without exercise on reducing the effects of exercise induced muscle damage(EIMD).

    PubMed, Embase, Web of science, and PEDro(Physiotherapy Evidence Database) were searched up to December 2019 for studies that…[Read more]

  • To identify health professionals awareness of stroke rehabilitation guidelines, and factors perceived to influence guideline use internationally.

    Online survey study. Open-ended responses were thematically analysed, guided by the Consolidated Framework for Implementation Research.

    Data from 833 respondents from 30 countries were…[Read more]

  • Fox Hester posted an update 9 months, 1 week ago

    1 MPa), and the elongation is 19.9%, 39.8% lower than that of pure aluminum (33.1%).This study examined the cross-sectional and longitudinal association of sleep timing with weight status in 14- to 19-year-old adolescents in Wuhan, China. A prospective school-based study was conducted in Wuhan, China between 28 May and 29 September 2019. Data on…[Read more]

  • We do believe that a rapid reduction of all modifiable risk factors, especially obesity with its metabolic complications, should be a pillar of public health policies and interventions, in view of future waves of SARS-CoV-2 infection.Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to…[Read more]

  • Cancer is one of the most serious health concerns in 21st century whose prevalence is beyond boundaries and can affect any organ of human beings. The conventional chemotherapeutic treatment strategies lack specificity to tumours and are associated with toxic effects on immune system and other organ systems. In the past decades, there has been a…[Read more]

  • PERCIST measurements were performed for each paired baseline and post-treatment scan. Receiver operating characteristic analysis for the prediction of pCR was performed using logistic regression that included age and tumor size as covariates. SUV and SUL metrics were significantly different between orientation (P .6). Overlapping 95% confidence…[Read more]

  • A unique lanthanide complex which responds to near-infrared (NIR) stimulation was developed for remote regulation of cellular events. This molecule can be localized specifically on the cell surface. Upon NIR stimulation, strong emission of the complex can successfully modulate the activities of light-gated membrane channels and regulate the ion…[Read more]

  • Leishmaniasis is a neglected disease caused by Leishmania. Chemotherapy remains the mainstay for leishmaniasis control; however, available drugs fail to provide a parasitological cure, and are associated with high toxicity. Natural products are promising leads for the development of novel chemotherapeutics against leishmaniasis. This work…[Read more]

  • Sauer Leth posted an update 9 months, 1 week ago

    Sexual and gender minority (SGM) individuals experience minority stress, especially when they lack social support. SGM young adults may turn to social media in search of a supportive community; however, social media use can become problematic when it interferes with functioning. Problematic social media use may be associated with experiences of…[Read more]

  • FGF-23 has arisen as an early biomarker of renal dysfunction, but at the onset of chronic kidney disease (CKD) data suggest that FGF-23 may be produced independently of the parathyroid hormone (PTH), 1,25(OH)2 -Vitamin D3 signaling axis. Iron status is inversely correlated to the level of circulating FGF-23, and improvement in iron bioavailability…[Read more]

  • Myalgia, increased levels of creatine kinase, and persistent muscle weakness have been reported in patients with COVID-19.

    To study skeletal muscle and myocardial inflammation in patients with COVID-19 who had died.

    This case-control autopsy series was conducted in a university hospital as a multidisciplinary postmortem…[Read more]

  • This is a long enough period of time for the recipients to fully appreciate the benefits of the procedure and for the donor families to see the effects of their decision (the opinion and the Law proposal hit the Zeitgeist, and keep Italy in the regulation of European Union).Diffuse IDH-mutant astrocytic tumors are rarely diagnosed in the…[Read more]

  • 0 days. Patient engagement in the decision-making process should include considerations of patient knowledge of, and experience with, the various treatment options. © 2020 American Academy of Physical Medicine and Rehabilitation.BACKGROUND The use of platelet-rich plasma (PRP) combined with noninvasive, nonenergy procedures for atrophic acne sc…[Read more]

  • Basal-like breast cancers (BBC) exhibit subtype-specific phenotypic and transcriptional responses to stroma, but little research has addressed how stromal-epithelial interactions evolve during early BBC carcinogenesis. It is also unclear how common genetic defects, such as p53 mutations, modify these stromal-epithelial interactions. To address…[Read more]

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