• 8-OHdG immunoexpression, DNA damage, cytochrome C and catalase gene expressions and Toll like signaling pathway (TLR2, and pIKKα/β) decreased in animals treated with grape juice when compared to cadmium group.

    Taken together, we conclude that grape and apple juices had a protective effect by means of antioxidant, antigenotoxic actions a…[Read more]

  • Inotersen (TEGSEDI™) is a 2′-O-(2-methoxyethyl)-modified antisense oligonucleotide, intended for treating hereditary transthyretin (TTR) amyloidosis with polyneuropathy. The potential immunogenicity (IM) response to inotersen was evaluated in chronic nonclinical safety studies and the pivotal phase 2/3 clinical study. The evaluation was designed…[Read more]

  • Chronic stress exposure impacts negatively in individuals leading to food addiction, overweight or obesity. Stress-genes and their translation products are responsible for the responses of humans to adverse environments. Alterations in stress-genes expression or protein function may induce behaviors as compulsive eating of high-energy containing…[Read more]

  • Plants transition through juvenile and adult phases of vegetative development in a process known as vegetative phase change (VPC). In poplars (genus Populus) the differences between these stages are subtle, making it difficult to determine when this transition occurs. Previous studies of VPC in poplars have relied on plants propagated in vitro,…[Read more]

  • Moreover, this pilot study demonstrated the need to deliver a more effective trauma treatment teaching for hemorrhagic lesions and that hemorrhagic trauma simulators can be used to train and evaluate different scenarios.The usage of insects as an alternative protein source for broiler feeds may help to reduce the dependency on soybean meal (SBM)…[Read more]

  • 026, HR=8.385, 95%CI=1.293-54.367). Although no relationship between PD-L1 expression pattern and prognosis was observed,”diffuse-pattern” of the PD-L1 expression was related to lymphatic-vascular invasion (P=0.007) and infiltration depth (P=0.04). Among the patients with MSI-H and PD-L1 positive gastric cancer, the patients who experienced…[Read more]

  • BACKGROUND Fusarium solani f. sp. piperis is a phytopathogen that causes one of the most destructive diseases in black pepper crops, resulting in significant economic and crop production losses. Consequently, the control of this fungal disease is a matter of current and relevant interest for agriculture. OBJECTIVE The objective was to synthesize…[Read more]

  • Results Twenty studies were included and were all of generally high quality. Cohort size, length of follow-up, measurement objectives, data acquisition, and data analysis all varied considerably across studies, precluding meta-analysis. However, study results correlating heart rate variability and relevant outcomes indicated that overall, heart…[Read more]

  • Moreover, this pilot study demonstrated the need to deliver a more effective trauma treatment teaching for hemorrhagic lesions and that hemorrhagic trauma simulators can be used to train and evaluate different scenarios.The usage of insects as an alternative protein source for broiler feeds may help to reduce the dependency on soybean meal (SBM)…[Read more]

  • The efficacy of acupuncture on advanced cancer care and outcomes has not yet been determined. Palliative care for patients with advanced cancer may involve multiple challenges that include physical and mental health care. This systematic review will offer updated and comprehensive evidence of acupuncture on specific outcomes induced by advanced…[Read more]

  • The urodele amphibians, salamanders and newts, represent the phylogenetic group closest to mammals capable of performing complete myocardial regeneration following ventricular resection. The resection model has generated a basic knowledge of the processes involved in cardiac repair. However, the model does not relate well to clinical situations in…[Read more]

  • Cox Iqbal posted an update 7 months, 3 weeks ago

    Working Memory (WM) plays a crucial role in supporting children’s mathematical learning. However, there is no consensus on the relative contributions of different WM domains (i.e., verbal, visuo-spatial, and numerical-verbal) and processes (i.e., low-control and high-control) to mathematical performance, specifically before and after the onset of…[Read more]

  • Chronic stress exposure impacts negatively in individuals leading to food addiction, overweight or obesity. Stress-genes and their translation products are responsible for the responses of humans to adverse environments. Alterations in stress-genes expression or protein function may induce behaviors as compulsive eating of high-energy containing…[Read more]

  • Patients treated with splenic artery embolization (SAE) >48 hours after a blunt injury for a delayed splenic rupture (DSR) were assessed for the need for a subsequent splenectomy. Thirty-four patients underwent SAE for DSR over 10 years at our level 1 trauma center, performed at a median of 4.5 days after the injury (interquartile range = 5.5),…[Read more]

  • Coinfection regarding Tuberculosis within an Undiagnosed Aids, Supports Patient Delivering Together with Shortness of Breath, Constitutional Signs or symptoms and also Lymphadenopathy.

    γ-Aminobutyric acid (GABA) is a widely distributed non-protein amino acid mediated the regulation of nitrate uptake and Al3+ tolerance in plants. However, there…[Read more]

  • t of an inevitably stressful work environment, hospitals have to focus on the individual interpretation of each job demand in order to manage the burnout and engagement of nurses. In addition, the scales have potential use in studies relevant to problems encountered in the nursing profession (e.g., opting to pursue a different career).

    Dairy…[Read more]

  • .Purpose Existing methods for checking the light field-radiation field congruence on x-ray equipment either do not fully meet the conditions of various quality control standards regarding inherent uncertainty requirements or contain subjective steps, further increasing the uncertainty of the end result. The aim of this work was to develop a method…[Read more]

  • We generated 194.52 GB clean base data from twenty-five sequencing libraries and identified 18,701 genes, including 3492 novel genes. With corrected p value 2, we finally obtained 921, 553, 574, 457, and 638 tissue-specific DEGs in the heart, liver, spleen, lung, and kidney, respectively. In addition, we identified TTN, CAV3, LDB3, TRDN, and A…[Read more]

  • Nance May posted an update 7 months, 3 weeks ago

    A basic paradigm underlying the Hookean mechanics of amorphous, isotropic solids is that small deformations are proportional to the magnitude of external forces. However, slender bodies may undergo large deformations even under minute forces, leading to nonlinear responses rooted in purely geometric effects. Here we study the indentation of a…[Read more]

  • Surgical site infection (SSI) following caesarean section is a serious but underreported problem with an estimated incidence of 5-9%. It is essential to identify adherence to established prevention strategies to reduce the incidence rate.

    The aims of this study were to quantify unwarranted variation from evidence-based practice on the…[Read more]

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